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TPRG1L tumor protein p63 regulated 1 like [ Homo sapiens (human) ]

Gene ID: 127262, updated on 27-Nov-2024

Summary

Official Symbol
TPRG1Lprovided by HGNC
Official Full Name
tumor protein p63 regulated 1 likeprovided by HGNC
Primary source
HGNC:HGNC:27007
See related
Ensembl:ENSG00000158109 MIM:611460; AllianceGenome:HGNC:27007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPRGL; mover; FAM79A; SVAP30; h-mover
Summary
Predicted to enable calmodulin binding activity and identical protein binding activity. Predicted to be involved in presynaptic modulation of chemical synaptic transmission; regulation of glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within calcineurin-NFAT signaling cascade; negative regulation of synaptic transmission; and synaptic vesicle docking. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 35.5), kidney (RPKM 30.0) and 25 other tissues See more
Orthologs
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Genomic context

See TPRG1L in Genome Data Viewer
Location:
1p36.32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (3625015..3630127)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (3135110..3140200)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3541579..3546691)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 6 Neighboring gene uncharacterized LOC105378608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3493527-3494026 Neighboring gene microRNA 551a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3506712-3507277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3507278-3507842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3508323-3509002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3513146-3514042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3529609-3530355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3530356-3531101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3535070-3535978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 60 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:3541953-3542615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:3557544-3558044 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3558876-3559121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3566888-3567731 Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 61 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 63 Neighboring gene TP73 antisense RNA 3 Neighboring gene tumor protein p73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21811

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle docking IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in calyx of Held ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome HDA PubMed 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor protein p63-regulated gene 1-like protein
Names
RP11-46F15.3
family with sequence similarity 79, member A
mossy fiber terminal-associated vertebrate-specific presynaptic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182752.4NP_877429.2  tumor protein p63-regulated gene 1-like protein

    See identical proteins and their annotated locations for NP_877429.2

    Status: VALIDATED

    Source sequence(s)
    AL513320, BC019034
    Consensus CDS
    CCDS47.1
    UniProtKB/Swiss-Prot
    A8K1K4, Q5T0D9, Q8WV04
    UniProtKB/TrEMBL
    B4DPH8
    Related
    ENSP00000367595.2, ENST00000378344.7
    Conserved Domains (1) summary
    pfam12456
    Location:67168
    hSac2; Inositol phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    3625015..3630127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    3135110..3140200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)