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Pakap paralemmin A kinase anchor protein [ Mus musculus (house mouse) ]

Gene ID: 677884, updated on 8-Jan-2023

Summary

Official Symbol
Pakapprovided by MGI
Official Full Name
paralemmin A kinase anchor proteinprovided by MGI
Primary source
MGI:MGI:5141924
See related
Ensembl:ENSMUSG00000038729 Ensembl:ENSMUSG00000089945 Ensembl:ENSMUSG00000090053 AllianceGenome:MGI:5141924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akap2; PRKA2; Palm2; pEN70; 53-H12; AKAP-2; R75368; AKAP-KL; Gm20459; AA959716; AI649048; B130066I24; Palm2Akap2; Palm2akap2; Palm2-Akap2; B230340M18Rik
Summary
This locus represents naturally occurring readthrough transcription between the neighboring Palm2 (paralemmin 2) and Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. Similar readthrough transcription has also been observed in human, as described in PMID: 11478809. [provided by RefSeq, Feb 2015]
Expression
Broad expression in lung adult (RPKM 57.1), adrenal adult (RPKM 18.2) and 20 other tissues See more
Orthologs
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Genomic context

See Pakap in Genome Data Viewer
Location:
4 B3; 4
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (57434475..57896984)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (57434475..57896984)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 12538 Neighboring gene predicted gene 12539 Neighboring gene VISTA enhancer mm1344 Neighboring gene VISTA enhancer mm27 Neighboring gene predicted gene, 52699 Neighboring gene predicted gene, 35099 Neighboring gene VISTA enhancer mm261 Neighboring gene RIKEN cDNA D630039A03 gene Neighboring gene predicted gene, 26138 Neighboring gene predicted gene, 42293

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5810, KIAA0920, MGC130608

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
paralemmin-2
Names
A kinase (PRKA) anchor protein 2
A-kinase anchor protein 2
AKAP expressed in kidney and lung
Palm2-Akap2 readthrough transcript
Protein kinase A-anchoring protein 2
paralemmin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035532.2NP_001030609.1  paralemmin-2 isoform 2

    See identical proteins and their annotated locations for NP_001030609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK046082, AK147420, AL840629
    Consensus CDS
    CCDS18203.1
    UniProtKB/Swiss-Prot
    O54931
    Related
    ENSMUSP00000103224.4, ENSMUST00000107598.9
    Conserved Domains (1) summary
    pfam15304
    Location:731872
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  2. NM_001035533.2NP_001030610.1  paralemmin-2 isoform 1

    See identical proteins and their annotated locations for NP_001030610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). The 5' UTR is incomplete due to a lack of 5'-complete transcripts representing this variant and the presence of splicing ambiguity in the 5' region.
    Source sequence(s)
    AK046082, AL840629, AW489512
    Consensus CDS
    CCDS18204.1
    UniProtKB/Swiss-Prot
    O54931, Q8C5W1
    Related
    ENSMUSP00000048678.6, ENSMUST00000043456.12
    Conserved Domains (1) summary
    pfam15304
    Location:608885
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  3. NM_001304544.1NP_001291473.1  paralemmin-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AK077020, AL772312, AL840629, BF469297
    UniProtKB/Swiss-Prot
    O54931
    Conserved Domains (3) summary
    COG1196
    Location:1129
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03285
    Location:67131
    Paralemmin
    pfam15304
    Location:6831068
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  4. NM_001384149.1NP_001371078.1  paralemmin-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL772312, AL772328, AL954706
    Conserved Domains (2) summary
    COG1196
    Location:2131
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03285
    Location:69378
    Paralemmin
  5. NM_001384150.1NP_001371079.1  paralemmin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL772312, AL840629
    Related
    ENSMUSP00000117466.2, ENSMUST00000150412.4
    Conserved Domains (3) summary
    COG1196
    Location:1129
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03285
    Location:67131
    Paralemmin
    pfam15304
    Location:8041081
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  6. NM_001384157.1NP_001371086.1  paralemmin-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL772312, AL772328, AL840629
    Conserved Domains (3) summary
    COG1196
    Location:2131
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03285
    Location:69133
    Paralemmin
    pfam15304
    Location:8061083
    AKAP2_C; A-kinase anchor protein 2 C-terminus
  7. NM_009649.3NP_033779.2  paralemmin-2 isoform 3

    See identical proteins and their annotated locations for NP_033779.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK041873, AK046082, AL840629
    Consensus CDS
    CCDS18205.1
    UniProtKB/TrEMBL
    Q8C9L6
    Related
    ENSMUSP00000099967.2, ENSMUST00000102903.8
  8. NM_172868.3NP_766456.1  paralemmin-2 isoform 5

    See identical proteins and their annotated locations for NP_766456.1

    Status: VALIDATED

    Source sequence(s)
    AK045344, AL954706, BM938241
    Consensus CDS
    CCDS18202.1
    UniProtKB/Swiss-Prot
    Q8BR92
    Related
    ENSMUSP00000099968.4, ENSMUST00000102904.10
    Conserved Domains (1) summary
    pfam03285
    Location:67376
    Paralemmin; Paralemmin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    57434475..57896984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)