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Faxdc2 fatty acid hydroxylase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 676527, updated on 17-Aug-2024

Summary

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Official Symbol
Faxdc2provided by MGI
Official Full Name
fatty acid hydroxylase domain containing 2provided by MGI
Primary source
MGI:MGI:3651124
See related
Ensembl:ENSMUSG00000086962 AllianceGenome:MGI:3651124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm247; Gm12248
Summary
Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 35.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57954508..57983977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58063682..58093196, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29589 Neighboring gene STARR-positive B cell enhancer ABC_E8407 Neighboring gene STARR-positive B cell enhancer ABC_E10676 Neighboring gene reduced expression 3 (Rex3) pseudogene Neighboring gene STARR-seq mESC enhancer starr_29598 Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene predicted gene, 51897 Neighboring gene STARR-positive B cell enhancer ABC_E10677 Neighboring gene STARR-seq mESC enhancer starr_29600 Neighboring gene predicted gene 12247 Neighboring gene CCR4-NOT transcription complex, subunit 8 Neighboring gene gem nuclear organelle associated protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-4 methylsterol oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty acid hydroxylase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378239.1 → NP_001365168.1  fatty acid hydroxylase domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AL672182
    UniProtKB/TrEMBL
    A0A1W2P6W1, A0A1W2P8B8
    Related
    ENSMUSP00000151997.2, ENSMUST00000219877.2
    Conserved Domains (1) summary
    pfam04116
    Location:152 → 276
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    57954508..57983977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246462.2 → XP_030102322.1  fatty acid hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A1W2P846
    Conserved Domains (1) summary
    pfam04116
    Location:130 → 254
    FA_hydroxylase; Fatty acid hydroxylase superfamily
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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