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FAXDC2 fatty acid hydroxylase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 10826, updated on 7-Jun-2020

Summary

Official Symbol
FAXDC2provided by HGNC
Official Full Name
fatty acid hydroxylase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:1334
See related
Ensembl:ENSG00000170271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5orf4
Expression
Ubiquitous expression in liver (RPKM 20.9), ovary (RPKM 19.8) and 25 other tissues See more
Orthologs

Genomic context

See FAXDC2 in Genome Data Viewer
Location:
5q33.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (154817018..154850683, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154196594..154230213, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene ribosomal protein L21 pseudogene 57 Neighboring gene uncharacterized LOC112267936 Neighboring gene microRNA 378h Neighboring gene CCR4-NOT transcription complex subunit 8 Neighboring gene gem nuclear organelle associated protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13758

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-4 methylsterol oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fatty acid hydroxylase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032385.5NP_115761.2  fatty acid hydroxylase domain-containing protein 2

    See identical proteins and their annotated locations for NP_115761.2

    Status: VALIDATED

    Source sequence(s)
    BC007216
    Consensus CDS
    CCDS43390.1
    UniProtKB/Swiss-Prot
    Q96IV6
    Related
    ENSP00000320604.5, ENST00000326080.10
    Conserved Domains (1) summary
    pfam04116
    Location:175299
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    154817018..154850683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008965.1XP_016864454.1  fatty acid hydroxylase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q96IV6
    Conserved Domains (1) summary
    pfam04116
    Location:175299
    FA_hydroxylase; Fatty acid hydroxylase superfamily
  2. XM_006714753.2XP_006714816.1  fatty acid hydroxylase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006714816.1

    UniProtKB/Swiss-Prot
    Q96IV6
    Conserved Domains (1) summary
    pfam04116
    Location:175299
    FA_hydroxylase; Fatty acid hydroxylase superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016348.1: Suppressed sequence

    Description
    NM_016348.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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