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Dusp6 dual specificity phosphatase 6 [ Mus musculus (house mouse) ]

Gene ID: 67603, updated on 2-Apr-2024

Summary

Official Symbol
Dusp6provided by MGI
Official Full Name
dual specificity phosphatase 6provided by MGI
Primary source
MGI:MGI:1914853
See related
Ensembl:ENSMUSG00000019960 AllianceGenome:MGI:1914853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MKP3; MKP-3; PYST1; 1300019I03Rik
Summary
Enables phosphoprotein phosphatase activity. Acts upstream of or within negative regulation of protein phosphorylation; protein dephosphorylation; and regulation of heart growth. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; renal cortex; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 46.1), adrenal adult (RPKM 45.5) and 28 other tissues See more
Orthologs
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Genomic context

See Dusp6 in Genome Data Viewer
Location:
10 D1; 10 51.13 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (99098676..99103351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99263231..99267489)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34574 Neighboring gene STARR-seq mESC enhancer starr_27709 Neighboring gene predicted gene, 34777 Neighboring gene STARR-seq mESC enhancer starr_27710 Neighboring gene STARR-positive B cell enhancer ABC_E5177 Neighboring gene predicted gene, 34921 Neighboring gene predicted gene, 48089 Neighboring gene STARR-seq mESC enhancer starr_27713 Neighboring gene uncharacterized LOC118567817 Neighboring gene STARR-seq mESC enhancer starr_27715 Neighboring gene STARR-seq mESC enhancer starr_27716 Neighboring gene STARR-positive B cell enhancer ABC_E2338 Neighboring gene STARR-seq mESC enhancer starr_27718

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC98540

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 6
Names
MAP kinase phosphatase 3
mitogen-activated protein kinase phosphatase 3
NP_080544.1
XP_036011858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026268.3NP_080544.1  dual specificity protein phosphatase 6

    See identical proteins and their annotated locations for NP_080544.1

    Status: VALIDATED

    Source sequence(s)
    AK159502, BQ176279, CJ278479
    Consensus CDS
    CCDS24147.1
    UniProtKB/Swiss-Prot
    Q542I5, Q9D7L4, Q9DBB1
    UniProtKB/TrEMBL
    Q3U786
    Related
    ENSMUSP00000020118.5, ENSMUST00000020118.5
    Conserved Domains (3) summary
    COG2453
    Location:204356
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:207344
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:18147
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    99098676..99103351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155965.1XP_036011858.1  dual specificity protein phosphatase 6 isoform X1

    UniProtKB/TrEMBL
    A0A1W2P715
    Related
    ENSMUSP00000151438.2, ENSMUST00000220291.2
    Conserved Domains (2) summary
    cd01446
    Location:18134
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cl28904
    Location:134197
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily