Format

Send to:

Choose Destination

DUSP6 dual specificity phosphatase 6 [ Homo sapiens (human) ]

Gene ID: 1848, updated on 3-May-2020

Summary

Official Symbol
DUSP6provided by HGNC
Official Full Name
dual specificity phosphatase 6provided by HGNC
Primary source
HGNC:HGNC:3072
See related
Ensembl:ENSG00000139318 MIM:602748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH19; MKP3; PYST1
Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 46.5), fat (RPKM 44.7) and 24 other tissues See more
Orthologs

Genomic context

See DUSP6 in Genome Data Viewer
Location:
12q21.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (89347235..89352501, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (89741837..89746296, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 120 pseudogene Neighboring gene mitochondrial ribosomal protein S6 pseudogene 4 Neighboring gene POC1 centriolar protein B Neighboring gene centromere protein C pseudogene 1 Neighboring gene POC1B-GALNT4 readthrough Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
inactivation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of heart growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to growth factor IEA
Inferred from Electronic Annotation
more info
 
response to nitrosative stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 6
Names
MAP kinase phosphatase 3
dual specificity protein phosphatase PYST1
mitogen-activated protein kinase phosphatase 3
serine/threonine specific protein phosphatase
NP_001937.2
NP_073143.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033915.1 RefSeqGene

    Range
    5359..10625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001946.4NP_001937.2  dual specificity protein phosphatase 6 isoform a

    See identical proteins and their annotated locations for NP_001937.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC024909, BC003143, BC037236, BF087219, DA105027
    Consensus CDS
    CCDS9033.1
    UniProtKB/Swiss-Prot
    Q16828
    UniProtKB/TrEMBL
    A0A024RBC1
    Related
    ENSP00000279488.6, ENST00000279488.8
    Conserved Domains (2) summary
    cd00127
    Location:207344
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:17147
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
  2. NM_022652.4NP_073143.2  dual specificity protein phosphatase 6 isoform b

    See identical proteins and their annotated locations for NP_073143.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting shorter isoform (b) lacks an internal protein segment compared to isoform a.
    Source sequence(s)
    AC024909, AK222882, BC003143, BC037236, BF087219, DA105027
    Consensus CDS
    CCDS9034.1
    UniProtKB/Swiss-Prot
    Q16828
    UniProtKB/TrEMBL
    Q53GP9
    Related
    ENSP00000307835.6, ENST00000308385.6
    Conserved Domains (2) summary
    cd00127
    Location:124198
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:17134
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    89347235..89352501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center