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SSTR3 somatostatin receptor 3 [ Homo sapiens (human) ]

Gene ID: 6753, updated on 22-Aug-2020

Summary

Official Symbol
SSTR3provided by HGNC
Official Full Name
somatostatin receptor 3provided by HGNC
Primary source
HGNC:HGNC:11332
See related
Ensembl:ENSG00000278195 MIM:182453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SS3R; SS3-R; SS-3-R; SSR-28
Summary
This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in testis (RPKM 3.5), brain (RPKM 1.1) and 8 other tissues See more
Orthologs

Genomic context

See SSTR3 in Genome Data Viewer
Location:
22q13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (37204237..37220451, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37600277..37616472, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene interleukin 2 receptor subunit beta Neighboring gene IL2RB LTR promoter Neighboring gene C1q and TNF related 6 Neighboring gene ribosomal protein L39 pseudogene 41 Neighboring gene Rac family small GTPase 2 Neighboring gene uncharacterized LOC107985576

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Joint influence of small-effect genetic variants on human longevity.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
somatostatin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to starvation IEA
Inferred from Electronic Annotation
more info
 
somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
ciliary membrane TAS
Traceable Author Statement
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
somatostatin receptor type 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001051.5NP_001042.1  somatostatin receptor type 3

    See identical proteins and their annotated locations for NP_001042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK291165, BF514979, Z82188
    Consensus CDS
    CCDS13944.1
    UniProtKB/Swiss-Prot
    P32745
    Related
    ENSP00000480971.1, ENST00000610913.2
    Conserved Domains (2) summary
    pfam00001
    Location:61313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55158
    7tm_4; Olfactory receptor
  2. NM_001278687.2NP_001265616.1  somatostatin receptor type 3

    See identical proteins and their annotated locations for NP_001265616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BF514979, BU584980, KF511460, Z82188
    Consensus CDS
    CCDS13944.1
    UniProtKB/Swiss-Prot
    P32745
    Related
    ENSP00000481325.1, ENST00000617123.1
    Conserved Domains (2) summary
    pfam00001
    Location:61313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55158
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    37204237..37220451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261721.4XP_005261778.1  somatostatin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_005261778.1

    UniProtKB/Swiss-Prot
    P32745
    Conserved Domains (2) summary
    pfam00001
    Location:61313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55158
    7tm_4; Olfactory receptor
  2. XM_011530349.2XP_011528651.1  somatostatin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_011528651.1

    UniProtKB/Swiss-Prot
    P32745
    Conserved Domains (2) summary
    pfam00001
    Location:61313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55158
    7tm_4; Olfactory receptor
  3. XM_017028924.1XP_016884413.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    P32745
    Conserved Domains (2) summary
    pfam00001
    Location:61313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55158
    7tm_4; Olfactory receptor
  4. XM_017028923.1XP_016884412.1  somatostatin receptor type 3 isoform X1

    UniProtKB/Swiss-Prot
    P32745
    Conserved Domains (2) summary
    pfam00001
    Location:61313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55158
    7tm_4; Olfactory receptor
  5. XM_006724311.3XP_006724374.1  somatostatin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_006724374.1

    UniProtKB/Swiss-Prot
    P32745
    Conserved Domains (2) summary
    pfam00001
    Location:61313
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:55158
    7tm_4; Olfactory receptor
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