Trim62 tripartite motif-containing 62 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim62provided by MGI
Official Full Name: tripartite motif-containing 62provided by MGI
Primary source: MGI:MGI:1914775
See related: Ensembl:ENSMUSG00000041000 AllianceGenome:MGI:1914775
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dear1; 6330414G21Rik
Summary: Predicted to enable identical protein binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in positive regulation of antifungal innate immune response. Acts upstream of or within negative regulation of epithelial to mesenchymal transition. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; maxillary process; sensory organ; and submandibular gland primordium. Orthologous to human TRIM62 (tripartite motif containing 62). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 21.1), ovary adult (RPKM 7.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 62.38 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (128777837..128805119)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (128884044..128911326)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM62 knockout protects against cerebral ischemic injury in mice by suppressing NLRP3-regulated neuroinflammation.
Title: TRIM62 knockout protects against cerebral ischemic injury in mice by suppressing NLRP3-regulated neuroinflammation.
Ubiquitination of CARD9 by TRIM62 regulates CARD9-mediated anti-fungal immunity. Trim62-deficient mice had increased susceptibility to fungal infection.
Title: Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.
Trim62 loss cooperates with K-Ras mutation in tumourigenesis and metastasis in vivo, indicating that decreased levels of TRIM62 may play an important role in the evolution of lung cancer.
Title: Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI450348 (e-PCR)
- UniSTS:159297

D5Rat238 (e-PCR), detects polymorphism
- UniSTS:227937

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antifungal innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein K27-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in viral release from host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM62

Names: RING-type E3 ubiquitin transferase TRIM62; tripartite motif-containing protein 62

NP_001357685.1

EC 2.3.2.27

NP_001357686.1

EC 2.3.2.27

NP_835211.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370756.1 → NP_001357685.1 E3 ubiquitin-protein ligase TRIM62 isoform 1

Status: VALIDATED

Source sequence(s)

AL607086

Conserved Domains (4) summary

COG1196
Location:133 → 267

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd13744
Location:290 → 477

SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)

pfam00643
Location:91 → 128

zf-B_box; B-box zinc finger

cd16608
Location:6 → 55

RING-HC_TRIM62_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 62 (TRIM62) and similar proteins
NM_001370757.1 → NP_001357686.1 E3 ubiquitin-protein ligase TRIM62 isoform 3

Status: VALIDATED

Source sequence(s)

AL607086

Conserved Domains (4) summary

smart00502
Location:128 → 223

BBC; B-Box C-terminal domain

TIGR00599
Location:9 → 148

rad18; DNA repair protein rad18

cd13744
Location:252 → 439

SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)

cd16608
Location:6 → 55

RING-HC_TRIM62_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 62 (TRIM62) and similar proteins
NM_178110.3 → NP_835211.1 E3 ubiquitin-protein ligase TRIM62 isoform 2

See identical proteins and their annotated locations for NP_835211.1

Status: VALIDATED

Source sequence(s)

AL607086

Consensus CDS

CCDS18677.1

UniProtKB/Swiss-Prot

Q80V85

Related

ENSMUSP00000039121.9, ENSMUST00000035667.9

Conserved Domains (4) summary

pfam00643
Location:91 → 128

zf-B_box; B-box zinc finger

cd13744
Location:284 → 471

SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)

cl17238
Location:11 → 53

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl23765
Location:136 → 255

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits