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Trim62 tripartite motif-containing 62 [ Mus musculus (house mouse) ]

Gene ID: 67525, updated on 8-Feb-2024

Summary

Official Symbol
Trim62provided by MGI
Official Full Name
tripartite motif-containing 62provided by MGI
Primary source
MGI:MGI:1914775
See related
Ensembl:ENSMUSG00000041000 AllianceGenome:MGI:1914775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dear1; 6330414G21Rik
Summary
Predicted to enable identical protein binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in positive regulation of antifungal innate immune response. Acts upstream of or within negative regulation of epithelial to mesenchymal transition. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; maxillary process; sensory organ; and submandibular gland primordium. Orthologous to human TRIM62 (tripartite motif containing 62). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 21.1), ovary adult (RPKM 7.9) and 19 other tissues See more
Orthologs
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Genomic context

See Trim62 in Genome Data Viewer
Location:
4 D2.2; 4 62.38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128777837..128805119)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128884044..128911326)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 33814 Neighboring gene predicted gene, 54259 Neighboring gene predicted gene, 33901 Neighboring gene STARR-positive B cell enhancer ABC_E6221 Neighboring gene predicted gene, 57685

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of antifungal innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of antifungal innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM62
Names
RING-type E3 ubiquitin transferase TRIM62
tripartite motif-containing protein 62
NP_001357685.1
NP_001357686.1
NP_835211.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370756.1NP_001357685.1  E3 ubiquitin-protein ligase TRIM62 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607086
    Conserved Domains (4) summary
    COG1196
    Location:133267
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13744
    Location:290477
    SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)
    pfam00643
    Location:91128
    zf-B_box; B-box zinc finger
    cd16608
    Location:655
    RING-HC_TRIM62_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 62 (TRIM62) and similar proteins
  2. NM_001370757.1NP_001357686.1  E3 ubiquitin-protein ligase TRIM62 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL607086
    Conserved Domains (4) summary
    smart00502
    Location:128223
    BBC; B-Box C-terminal domain
    TIGR00599
    Location:9148
    rad18; DNA repair protein rad18
    cd13744
    Location:252439
    SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)
    cd16608
    Location:655
    RING-HC_TRIM62_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 62 (TRIM62) and similar proteins
  3. NM_178110.3NP_835211.1  E3 ubiquitin-protein ligase TRIM62 isoform 2

    See identical proteins and their annotated locations for NP_835211.1

    Status: VALIDATED

    Source sequence(s)
    AL607086
    Consensus CDS
    CCDS18677.1
    UniProtKB/Swiss-Prot
    Q80V85
    Related
    ENSMUSP00000039121.9, ENSMUST00000035667.9
    Conserved Domains (4) summary
    pfam00643
    Location:91128
    zf-B_box; B-box zinc finger
    cd13744
    Location:284471
    SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)
    cl17238
    Location:1153
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:136255
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    128777837..128805119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)