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TRIM62 tripartite motif containing 62 [ Homo sapiens (human) ]

Gene ID: 55223, updated on 18-Aug-2020

Summary

Official Symbol
TRIM62provided by HGNC
Official Full Name
tripartite motif containing 62provided by HGNC
Primary source
HGNC:HGNC:25574
See related
Ensembl:ENSG00000116525 MIM:616755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEAR1
Expression
Ubiquitous expression in skin (RPKM 2.0), brain (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See TRIM62 in Genome Data Viewer
Location:
1p35.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (33145399..33184774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33611000..33647671, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378635 Neighboring gene antizyme inhibitor 2 Neighboring gene uncharacterized LOC112268224 Neighboring gene zinc finger protein 362 Neighboring gene alpha 1,3-galactosyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Gene silencing of endogenously expressed TRIM62 inhibits viral release, suggesting the interaction between HIV-1 Gag and TRIM62 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10759, FLJ16558

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM62
Names
RING-type E3 ubiquitin transferase TRIM62
ductal epithelium-associated RING Chromosome 1
tripartite motif-containing protein 62
NP_001317412.1
NP_060677.2
XP_016857118.1
XP_016857119.1
XP_016857120.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330483.2NP_001317412.1  E3 ubiquitin-protein ligase TRIM62 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK300177, AL662907, BC001222
    Consensus CDS
    CCDS81297.1
    UniProtKB/Swiss-Prot
    Q9BVG3
    Related
    ENSP00000441173.1, ENST00000543586.1
  2. NM_018207.3NP_060677.2  E3 ubiquitin-protein ligase TRIM62 isoform 1

    See identical proteins and their annotated locations for NP_060677.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK001621, AL662907, BC007999, BM722392, CX872720, DA338982
    Consensus CDS
    CCDS376.1
    UniProtKB/Swiss-Prot
    Q9BVG3
    Related
    ENSP00000291416.5, ENST00000291416.10
    Conserved Domains (4) summary
    smart00336
    Location:88125
    BBOX; B-Box-type zinc finger
    cd13744
    Location:284471
    SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)
    cl17238
    Location:1153
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:136255
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    33145399..33184774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001630.1XP_016857119.1  E3 ubiquitin-protein ligase TRIM62 isoform X2

  2. XM_017001629.2XP_016857118.1  E3 ubiquitin-protein ligase TRIM62 isoform X1

  3. XM_017001631.1XP_016857120.1  E3 ubiquitin-protein ligase TRIM62 isoform X3

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