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Ufl1 UFM1 specific ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 67490, updated on 25-May-2024

Summary

Official Symbol
Ufl1provided by MGI
Official Full Name
UFM1 specific ligase 1provided by MGI
Primary source
MGI:MGI:1914740
See related
Ensembl:ENSMUSG00000040359 AllianceGenome:MGI:1914740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rcad; Maxer; Kiaa0776; mKIAA0776; 1810074P20Rik
Summary
Predicted to enable UFM1 ligase activity and protein kinase binding activity. Involved in hemopoiesis; positive regulation of autophagy; and response to endoplasmic reticulum stress. Acts upstream of or within positive regulation of glial cell proliferation; regulation of gene expression; and response to L-glutamate. Located in cytoplasm and neuron projection. Is expressed in cerebellum; cerebral cortex; and liver. Orthologous to human UFL1 (UFM1 specific ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.4), CNS E11.5 (RPKM 3.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ufl1 in Genome Data Viewer
Location:
4 A3; 4 10.59 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (25247149..25281821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (25247149..25281821, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C230012O17 gene Neighboring gene G protein-coupled receptor 63 Neighboring gene four and a half LIM domains 5 Neighboring gene peroxiredoxin 6 pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_09786 Neighboring gene STARR-seq mESC enhancer starr_09787 Neighboring gene ZW10 homolog, centromere/kinetochore protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UFM1 ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables UFM1 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein binding TAS
Traceable Author Statement
more info
PubMed 
involved_in protein K69-linked ufmylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K69-linked ufmylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein ufmylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein ufmylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within response to L-glutamate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in reticulophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 UFM1-protein ligase 1
Names
E3 UFM1-protein transferase 1
multiple alpha-helix protein located at ER
regulator of C53/LZAP and DDRGK1
NP_001342441.1
NP_080470.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355512.1NP_001342441.1  E3 UFM1-protein ligase 1

    Status: VALIDATED

    Source sequence(s)
    AK132697, AL365061, AL935267, BM900014, BY097965
    Consensus CDS
    CCDS18010.1
    UniProtKB/Swiss-Prot
    A2RSP7, B1AXU5, B1AXU6, Q3V145, Q6ZQ50, Q8BT70, Q8C484, Q8CCJ3, Q9D8I8
    Conserved Domains (1) summary
    pfam09743
    Location:7275
    E3_UFM1_ligase; E3 UFM1-protein ligase 1
  2. NM_026194.5NP_080470.2  E3 UFM1-protein ligase 1

    See identical proteins and their annotated locations for NP_080470.2

    Status: VALIDATED

    Source sequence(s)
    AK132697, AL935267, BM900014, BY097965
    Consensus CDS
    CCDS18010.1
    UniProtKB/Swiss-Prot
    A2RSP7, B1AXU5, B1AXU6, Q3V145, Q6ZQ50, Q8BT70, Q8C484, Q8CCJ3, Q9D8I8
    Related
    ENSMUSP00000100059.4, ENSMUST00000102994.10
    Conserved Domains (1) summary
    pfam09743
    Location:7275
    E3_UFM1_ligase; E3 UFM1-protein ligase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    25247149..25281821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)