Format

Send to:

Choose Destination

UFL1 UFM1 specific ligase 1 [ Homo sapiens (human) ]

Gene ID: 23376, updated on 2-Mar-2021

Summary

Official Symbol
UFL1provided by HGNC
Official Full Name
UFM1 specific ligase 1provided by HGNC
Primary source
HGNC:HGNC:23039
See related
Ensembl:ENSG00000014123 MIM:613372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLBP; RCAD; Maxer; KIAA0776
Expression
Ubiquitous expression in thyroid (RPKM 19.4), prostate (RPKM 15.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See UFL1 in Genome Data Viewer
Location:
6q16.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (96521806..96555276)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (96969682..97003152)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 797, pseudogene Neighboring gene UFL1 antisense RNA 1 Neighboring gene four and a half LIM domains 5 Neighboring gene ribosomal protein S7 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0776

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UFM1 ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
UFM1 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone modification IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of IRE1-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast differentiation HDA PubMed 
positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
protein K69-linked ufmylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K69-linked ufmylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphopantetheinylation IEA
Inferred from Electronic Annotation
more info
 
protein ufmylation IDA
Inferred from Direct Assay
more info
PubMed 
protein ufmylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
reticulophagy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 UFM1-protein ligase 1
Names
E3 UFM1-protein transferase 1
LZAP-binding protein
Regulator of CDK5RAP3 and DDRGK1
multiple alpha-helix protein located at ER
novel LZAP-binding protein
regulator of C53/LZAP and DDRGK1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015323.5NP_056138.1  E3 UFM1-protein ligase 1

    See identical proteins and their annotated locations for NP_056138.1

    Status: VALIDATED

    Source sequence(s)
    AB018319, AL590404, BC028608, BP337693
    Consensus CDS
    CCDS5034.1
    UniProtKB/Swiss-Prot
    O94874
    Related
    ENSP00000358283.4, ENST00000369278.5
    Conserved Domains (1) summary
    pfam09743
    Location:7275
    E3_UFM1_ligase; E3 UFM1-protein ligase 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    96521806..96555276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center