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UFL1 UFM1 specific ligase 1 [ Homo sapiens (human) ]

Gene ID: 23376, updated on 5-Jan-2022

Summary

Official Symbol
UFL1provided by HGNC
Official Full Name
UFM1 specific ligase 1provided by HGNC
Primary source
HGNC:HGNC:23039
See related
Ensembl:ENSG00000014123 MIM:613372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLBP; RCAD; Maxer; KIAA0776
Summary
Enables UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including cellular protein modification process; regulation of signal transduction; and reticulophagy. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of proteasomal ubiquitin-dependent protein catabolic process; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; nucleus; and site of double-strand break. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 19.4), prostate (RPKM 15.2) and 25 other tissues See more
Orthologs
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Genomic context

See UFL1 in Genome Data Viewer
Location:
6q16.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (96521806..96555276)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (96969682..97003152)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 797, pseudogene Neighboring gene UFL1 antisense RNA 1 Neighboring gene four and a half LIM domains 5 Neighboring gene ribosomal protein S7 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0776

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UFM1 ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables UFM1 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in histone modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of IRE1-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoblast differentiation HDA PubMed 
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K69-linked ufmylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K69-linked ufmylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ufmylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein ufmylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reticulophagy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 UFM1-protein ligase 1
Names
E3 UFM1-protein transferase 1
LZAP-binding protein
Regulator of CDK5RAP3 and DDRGK1
multiple alpha-helix protein located at ER
novel LZAP-binding protein
regulator of C53/LZAP and DDRGK1
NP_056138.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015323.5NP_056138.1  E3 UFM1-protein ligase 1

    See identical proteins and their annotated locations for NP_056138.1

    Status: VALIDATED

    Source sequence(s)
    AB018319, AL590404, BC028608, BP337693
    Consensus CDS
    CCDS5034.1
    UniProtKB/Swiss-Prot
    O94874
    Related
    ENSP00000358283.4, ENST00000369278.5
    Conserved Domains (1) summary
    pfam09743
    Location:7275
    E3_UFM1_ligase; E3 UFM1-protein ligase 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    96521806..96555276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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