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Decr1 2,4-dienoyl CoA reductase 1, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 67460, updated on 27-Feb-2024

Summary

Official Symbol
Decr1provided by MGI
Official Full Name
2,4-dienoyl CoA reductase 1, mitochondrialprovided by MGI
Primary source
MGI:MGI:1914710
See related
Ensembl:ENSMUSG00000028223 AllianceGenome:MGI:1914710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Decr; Nadph; 1200012F07Rik
Summary
Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Located in mitochondrion. Is expressed in axial skeleton. Orthologous to human DECR1 (2,4-dienoyl-CoA reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 41.1), liver E18 (RPKM 22.5) and 19 other tissues See more
Orthologs
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Genomic context

See Decr1 in Genome Data Viewer
Location:
4 A2; 4 6.66 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (15917240..15945377, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (15917240..15945377, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calbindin 1 Neighboring gene predicted gene, 26148 Neighboring gene microRNA 6400 Neighboring gene nibrin Neighboring gene STARR-positive B cell enhancer ABC_E6155 Neighboring gene oxidative stress induced growth inhibitor family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
Names
2,4-dienoyl-CoA reductase, mitochondrial
NP_080448.1
XP_036020258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026172.4NP_080448.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor

    See identical proteins and their annotated locations for NP_080448.1

    Status: VALIDATED

    Source sequence(s)
    BC046972
    Consensus CDS
    CCDS17985.1
    UniProtKB/Swiss-Prot
    Q9CQ62, Q9DCI7
    UniProtKB/TrEMBL
    Q4FJK0
    Related
    ENSMUSP00000029877.9, ENSMUST00000029877.9
    Conserved Domains (2) summary
    PRK07677
    Location:59303
    PRK07677; short chain dehydrogenase; Provisional
    cd05369
    Location:57303
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    15917240..15945377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164365.1XP_036020258.1  2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

    Conserved Domains (1) summary
    cd05369
    Location:7253
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR