Format

Send to:

Choose Destination

DECR1 2,4-dienoyl-CoA reductase 1 [ Homo sapiens (human) ]

Gene ID: 1666, updated on 1-Jun-2020

Summary

Official Symbol
DECR1provided by HGNC
Official Full Name
2,4-dienoyl-CoA reductase 1provided by HGNC
Primary source
HGNC:HGNC:2753
See related
Ensembl:ENSG00000104325 MIM:222745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DECR; NADPH; SDR18C1
Summary
This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 86.6), fat (RPKM 60.8) and 25 other tissues See more
Orthologs

Genomic context

See DECR1 in Genome Data Viewer
Location:
8q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (90001352..90053633)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (91013580..91064232)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene nibrin Neighboring gene Sharpr-MPRA regulatory region 13813 Neighboring gene calbindin 1 Neighboring gene GATA motif-containing MPRA enhancer 124

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
catalytic complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
2,4-dienoyl-CoA reductase, mitochondrial
Names
2,4-dienoyl-CoA reductase 1, mitochondrial
4-enoyl-CoA reductase
short chain dehydrogenase/reductase family 18C member 1
NP_001317504.1
NP_001350.1
XP_005250865.1
XP_011515182.1
XP_016868637.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008042.2 RefSeqGene

    Range
    5001..57157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330575.1NP_001317504.1  2,4-dienoyl-CoA reductase, mitochondrial isoform 2

    Status: REVIEWED

    Source sequence(s)
    AA247499, AA725334, AC004612, AF069291, AK300069
    Consensus CDS
    CCDS87618.1
    UniProtKB/Swiss-Prot
    Q16698
    Related
    ENSP00000429779.1, ENST00000522161.5
  2. NM_001359.2NP_001350.1  2,4-dienoyl-CoA reductase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001350.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA725334, AC004612, BC105080, CB104585, CR737790, H98841
    Consensus CDS
    CCDS6250.1
    UniProtKB/Swiss-Prot
    Q16698
    UniProtKB/TrEMBL
    A0A024R9D7
    Related
    ENSP00000220764.2, ENST00000220764.7
    Conserved Domains (1) summary
    cd05369
    Location:57303
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    90001352..90053633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250808.5XP_005250865.1  2,4-dienoyl-CoA reductase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd05369
    Location:1211
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
  2. XM_011516880.3XP_011515182.1  2,4-dienoyl-CoA reductase, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd05369
    Location:48294
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:48293
    PRK07576; short chain dehydrogenase; Provisional
  3. XM_017013148.1XP_016868637.1  2,4-dienoyl-CoA reductase, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q16698
    Conserved Domains (2) summary
    cd05369
    Location:48294
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:48293
    PRK07576; short chain dehydrogenase; Provisional
Support Center