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SSBP1 single stranded DNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 6742, updated on 9-Dec-2018

Summary

Official Symbol
SSBP1provided by HGNC
Official Full Name
single stranded DNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:11317
See related
Ensembl:ENSG00000106028 MIM:600439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSBP; mtSSB; Mt-SSB; SOSS-B1
Summary
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Expression
Ubiquitous expression in appendix (RPKM 9.8), adrenal (RPKM 9.6) and 25 other tissues See more
Orthologs

Genomic context

See SSBP1 in Genome Data Viewer
Location:
7q34
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (141738321..141750488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141438121..141450288)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene acylglycerol kinase Neighboring gene KIAA1147 Neighboring gene WEE2 antisense RNA 1 Neighboring gene WEE1 homolog 2 Neighboring gene RNA, U1 small nuclear 82, pseudogene Neighboring gene taste 2 receptor member 3 Neighboring gene taste 2 receptor member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with single-stranded DNA binding protein 1 (SSBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • DNA replication, organism-specific biosystem (from KEGG)
    DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • DNA replication, conserved biosystem (from KEGG)
    DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • Homologous recombination, organism-specific biosystem (from KEGG)
    Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Homologous recombination, conserved biosystem (from KEGG)
    Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Mismatch repair, organism-specific biosystem (from KEGG)
    Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
  • Mismatch repair, conserved biosystem (from KEGG)
    Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
  • Mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Mitochondrial biogenesis, organism-specific biosystemMitochondrial biogenesis and remodeling occur in response to exercise and redox state (reviewed in Scarpulla et al. 2012, Handy and Loscalzo 2012, Piantadosi and Suliman 2012, Scarpulla 2011, Wenz et...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
    Transcriptional activation of mitochondrial biogenesis, organism-specific biosystemPhosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization TAS
Traceable Author Statement
more info
 
positive regulation of helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
single-stranded DNA-binding protein, mitochondrial
Names
PWP1-interacting protein 17
single-stranded DNA binding protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256510.1NP_001243439.1  single-stranded DNA-binding protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001243439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    BC000895, BP308841
    Consensus CDS
    CCDS5866.1
    UniProtKB/Swiss-Prot
    Q04837
    UniProtKB/TrEMBL
    A4D1U3
    Related
    ENSP00000419665.1, ENST00000481508.1
    Conserved Domains (1) summary
    TIGR00621
    Location:27141
    ssb; single stranded DNA-binding protein (ssb)
  2. NM_001256511.1NP_001243440.1  single-stranded DNA-binding protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001243440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same protein.
    Source sequence(s)
    AF277319, BG030060, BP308841, BU532904
    Consensus CDS
    CCDS5866.1
    UniProtKB/Swiss-Prot
    Q04837
    UniProtKB/TrEMBL
    A4D1U3
    Related
    ENSP00000480488.1, ENST00000612337.4
    Conserved Domains (1) summary
    TIGR00621
    Location:27141
    ssb; single stranded DNA-binding protein (ssb)
  3. NM_001256512.1NP_001243441.1  single-stranded DNA-binding protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001243441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same protein.
    Source sequence(s)
    AF277319, BP308841, BQ959702, BU532904, DB464012
    Consensus CDS
    CCDS5866.1
    UniProtKB/Swiss-Prot
    Q04837
    UniProtKB/TrEMBL
    A4D1U3
    Related
    ENSP00000418068.1, ENST00000467681.5
    Conserved Domains (1) summary
    TIGR00621
    Location:27141
    ssb; single stranded DNA-binding protein (ssb)
  4. NM_001256513.1NP_001243442.1  single-stranded DNA-binding protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001243442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same protein.
    Source sequence(s)
    AF277319, AK313033, BP308841, BU532904
    Consensus CDS
    CCDS5866.1
    UniProtKB/Swiss-Prot
    Q04837
    UniProtKB/TrEMBL
    A4D1U3
    Related
    ENSP00000419541.1, ENST00000498107.5
    Conserved Domains (1) summary
    TIGR00621
    Location:27141
    ssb; single stranded DNA-binding protein (ssb)
  5. NM_003143.3NP_003134.1  single-stranded DNA-binding protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_003134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same protein.
    Source sequence(s)
    AF277319, BP308841, BU532904
    Consensus CDS
    CCDS5866.1
    UniProtKB/Swiss-Prot
    Q04837
    UniProtKB/TrEMBL
    A4D1U3
    Related
    ENSP00000265304.6, ENST00000265304.10
    Conserved Domains (1) summary
    TIGR00621
    Location:27141
    ssb; single stranded DNA-binding protein (ssb)

RNA

  1. NR_046269.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004918, AF277319, BF131408, BP308841, BU532904
    Related
    ENST00000469123.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    141738321..141750488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250049.5XP_005250106.1  single-stranded DNA-binding protein, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005250106.1

    UniProtKB/TrEMBL
    B7Z268
    Conserved Domains (2) summary
    COG0629
    Location:29134
    Ssb; Single-stranded DNA-binding protein [Replication, recombination and repair]
    TIGR00621
    Location:27134
    ssb; single stranded DNA-binding protein (ssb)
  2. XM_005250051.5XP_005250108.1  single-stranded DNA-binding protein, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005250108.1

    UniProtKB/TrEMBL
    B7Z268
    Conserved Domains (2) summary
    COG0629
    Location:29134
    Ssb; Single-stranded DNA-binding protein [Replication, recombination and repair]
    TIGR00621
    Location:27134
    ssb; single stranded DNA-binding protein (ssb)
  3. XM_005250048.5XP_005250105.1  single-stranded DNA-binding protein, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005250105.1

    UniProtKB/TrEMBL
    B7Z268
    Conserved Domains (2) summary
    COG0629
    Location:29134
    Ssb; Single-stranded DNA-binding protein [Replication, recombination and repair]
    TIGR00621
    Location:27134
    ssb; single stranded DNA-binding protein (ssb)
  4. XM_005250050.5XP_005250107.1  single-stranded DNA-binding protein, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005250107.1

    UniProtKB/TrEMBL
    B7Z268
    Conserved Domains (2) summary
    COG0629
    Location:29134
    Ssb; Single-stranded DNA-binding protein [Replication, recombination and repair]
    TIGR00621
    Location:27134
    ssb; single stranded DNA-binding protein (ssb)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003315922.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    110921..118190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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