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Cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 67337, updated on 2-Nov-2024

Summary

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Official Symbol
Cstf1provided by MGI
Official Full Name
cleavage stimulation factor, 3' pre-RNA, subunit 1provided by MGI
Primary source
MGI:MGI:1914587
See related
Ensembl:ENSMUSG00000027498 AllianceGenome:MGI:1914587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700057K18Rik
Summary
Predicted to be involved in mRNA 3'-end processing. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage stimulating factor complex. Is expressed in 1-cell stage embryo; 4-cell stage embryo; and compacted morula. Orthologous to human CSTF1 (cleavage stimulation factor subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 41.6), thymus adult (RPKM 23.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cstf1 in Genome Data Viewer
Location:
2 H3; 2 94.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172212591..172224369)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172370645..172382449)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14273 Neighboring gene family with sequence similarity 210, member B Neighboring gene aurora kinase A Neighboring gene STARR-seq mESC enhancer starr_06572 Neighboring gene STARR-positive B cell enhancer ABC_E823 Neighboring gene Cas scaffolding protein family member 4 Neighboring gene uncharacterized LOC118568483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172259262-172259485 Neighboring gene STARR-positive B cell enhancer ABC_E3425 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos. Li N, et al. Stem Cell Reports, 2023 Jan 10. PMID 36563685, Free PMC Article
  2. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Ewart-Toland A, et al. Nat Genet, 2003 Aug. PMID 12881723
  3. WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Pashkova N, et al. Mol Cell, 2010 Nov 12. PMID 21070969, Free PMC Article
  4. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. Goldbraikh D, et al. EMBO Rep, 2020 Apr 3. PMID 32133736, Free PMC Article
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage stimulating factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage stimulating factor complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cleavage stimulation factor subunit 1
Names
CF-1 50 kDa subunit
CSTF 50 kDa subunit
cleavage stimulation factor 50 kDa subunit
cstF-50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415874.1 → NP_001402803.1  cleavage stimulation factor subunit 1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    UniProtKB/Swiss-Prot
    Q3UMB8, Q8BJW1, Q99LC2, Q9CSU8

  2. NM_001415875.1 → NP_001402804.1  cleavage stimulation factor subunit 1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    UniProtKB/Swiss-Prot
    Q3UMB8, Q8BJW1, Q99LC2, Q9CSU8

  3. NM_024199.3 → NP_077161.1  cleavage stimulation factor subunit 1

    See identical proteins and their annotated locations for NP_077161.1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Consensus CDS
    CCDS17130.1
    UniProtKB/Swiss-Prot
    Q3UMB8, Q8BJW1, Q99LC2, Q9CSU8
    Related
    ENSMUSP00000112076.2, ENSMUST00000116375.2
    Conserved Domains (3) summary
    cd00200
    Location:100 → 424
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:116 → 171
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:8 → 59
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172212591..172224369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LC2.1 GenPept UniProtKB/Swiss-Prot:Q99LC2

Gene LinkOut

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