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Cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 67337, updated on 30-Apr-2024

Summary

Official Symbol
Cstf1provided by MGI
Official Full Name
cleavage stimulation factor, 3' pre-RNA, subunit 1provided by MGI
Primary source
MGI:MGI:1914587
See related
Ensembl:ENSMUSG00000027498 AllianceGenome:MGI:1914587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700057K18Rik
Summary
Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage stimulating factor complex. Orthologous to human CSTF1 (cleavage stimulation factor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 41.6), thymus adult (RPKM 23.7) and 28 other tissues See more
Orthologs
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Genomic context

See Cstf1 in Genome Data Viewer
Location:
2 H3; 2 94.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172212591..172224369)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172370645..172382449)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14273 Neighboring gene family with sequence similarity 210, member B Neighboring gene aurora kinase A Neighboring gene STARR-seq mESC enhancer starr_06572 Neighboring gene STARR-positive B cell enhancer ABC_E823 Neighboring gene Cas scaffolding protein family member 4 Neighboring gene uncharacterized LOC118568483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172259262-172259485 Neighboring gene STARR-positive B cell enhancer ABC_E3425 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of mRNA cleavage stimulating factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cleavage stimulation factor subunit 1
Names
CF-1 50 kDa subunit
CSTF 50 kDa subunit
cleavage stimulation factor 50 kDa subunit
cstF-50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415874.1NP_001402803.1  cleavage stimulation factor subunit 1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    UniProtKB/Swiss-Prot
    Q3UMB8, Q8BJW1, Q99LC2, Q9CSU8
  2. NM_001415875.1NP_001402804.1  cleavage stimulation factor subunit 1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    UniProtKB/Swiss-Prot
    Q3UMB8, Q8BJW1, Q99LC2, Q9CSU8
  3. NM_024199.3NP_077161.1  cleavage stimulation factor subunit 1

    See identical proteins and their annotated locations for NP_077161.1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Consensus CDS
    CCDS17130.1
    UniProtKB/Swiss-Prot
    Q3UMB8, Q8BJW1, Q99LC2, Q9CSU8
    Related
    ENSMUSP00000112076.2, ENSMUST00000116375.2
    Conserved Domains (3) summary
    cd00200
    Location:100424
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:116171
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:859
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172212591..172224369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)