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CSTF1 cleavage stimulation factor subunit 1 [ Homo sapiens (human) ]

Gene ID: 1477, updated on 21-Dec-2019

Summary

Official Symbol
CSTF1provided by HGNC
Official Full Name
cleavage stimulation factor subunit 1provided by HGNC
Primary source
HGNC:HGNC:2483
See related
Ensembl:ENSG00000101138 MIM:600369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CstF-50; CstFp50
Summary
This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See CSTF1 in Genome Data Viewer
Location:
20q13.2-q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (56392371..56406362)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (54967427..54979582)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210 member B Neighboring gene aurora kinase A Neighboring gene Cas scaffold protein family member 4 Neighboring gene ribosomal protein L39 pseudogene Neighboring gene replication termination factor 2 Neighboring gene uncharacterized LOC105372681 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mRNA cleavage stimulating factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cleavage stimulation factor subunit 1
Names
CF-1 50 kDa subunit
CSTF 50 kDa subunit
cleavage stimulation factor 50 kDa subunit
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kD
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033521.1NP_001028693.1  cleavage stimulation factor subunit 1

    See identical proteins and their annotated locations for NP_001028693.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a 5' UTR that is further upstream than the other variants. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BE958524, BI547689, BU189431, BU934383, L02547
    Consensus CDS
    CCDS13452.1
    UniProtKB/Swiss-Prot
    Q05048
    Conserved Domains (3) summary
    cd00200
    Location:100424
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:116171
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:762
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerisation domain
  2. NM_001033522.2NP_001028694.1  cleavage stimulation factor subunit 1

    See identical proteins and their annotated locations for NP_001028694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL121914, BE958524, BU189431, CF272312, L02547
    Consensus CDS
    CCDS13452.1
    UniProtKB/Swiss-Prot
    Q05048
    Conserved Domains (3) summary
    cd00200
    Location:100424
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:116171
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:762
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerisation domain
  3. NM_001324.3NP_001315.1  cleavage stimulation factor subunit 1

    See identical proteins and their annotated locations for NP_001315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL121914, BE958524, BU189431, BU189971, L02547
    Consensus CDS
    CCDS13452.1
    UniProtKB/Swiss-Prot
    Q05048
    Related
    ENSP00000217109.4, ENST00000217109.9
    Conserved Domains (3) summary
    cd00200
    Location:100424
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:116171
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:762
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerisation domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    56392371..56406362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528600.1XP_011526902.1  cleavage stimulation factor subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_011526902.1

    UniProtKB/Swiss-Prot
    Q05048
    Conserved Domains (3) summary
    cd00200
    Location:100424
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:116171
    7WD40; WD40 repeat [structural motif]
    pfam16699
    Location:762
    CSTF1_dimer; Cleavage stimulation factor subunit 1, dimerisation domain
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