Format

Send to:

Choose Destination

SRPK2 SRSF protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 6733, updated on 4-Nov-2018

Summary

Official Symbol
SRPK2provided by HGNC
Official Full Name
SRSF protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:11306
See related
Ensembl:ENSG00000135250 MIM:602980; Vega:OTTHUMG00000157405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFRSK2
Expression
Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues See more
Orthologs

Genomic context

See SRPK2 in Genome Data Viewer
Location:
7q22.3
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (105110708..105399363, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (104754048..105039614, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 2E Neighboring gene long intergenic non-protein coding RNA 1004 Neighboring gene KMT2E antisense RNA 1 Neighboring gene ribosomal protein L36 pseudogene 12 Neighboring gene RWD domain containing 4 pseudogene 1 Neighboring gene RNA, U6 small nuclear 1322, pseudogene Neighboring gene small integral membrane protein 12-like Neighboring gene ring finger protein 181 pseudogene Neighboring gene pseudouridine synthase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

Pathways from BioSystems

  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
innate immune response IC
Inferred by Curator
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
PubMed 
spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spliceosomal complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SRSF protein kinase 2
Names
SFRS protein kinase 2
SR protein kinase 2
SR-protein-specific kinase 2
serine kinase SRPK2
serine/arginine-rich protein-specific kinase 2
serine/arginine-rich splicing factor kinase 2
serine/threonine-protein kinase SRPK2
NP_001265202.1
NP_001337667.1
NP_001337668.1
NP_001337669.1
NP_001337670.1
NP_001337671.1
NP_001337672.1
NP_001337673.1
NP_001337674.1
NP_001337675.1
NP_872633.1
NP_872634.1
XP_006716161.1
XP_011514838.1
XP_011514840.1
XP_016868050.2
XP_024302661.1
XP_024302662.1
XP_024302663.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278273.1NP_001265202.1  SRSF protein kinase 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001265202.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC004884, AC005070, BC035214, BC068547, BU632662
    Consensus CDS
    CCDS5735.1
    UniProtKB/Swiss-Prot
    P78362
    UniProtKB/TrEMBL
    A0A024R704
    Related
    ENSP00000419791.1, OTTHUMP00000212093, ENST00000489828.5, OTTHUMT00000348717
    Conserved Domains (2) summary
    cl21453
    Location:68256
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  2. NM_001350738.1NP_001337667.1  SRSF protein kinase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC004884, AC005070, AC073138
    Consensus CDS
    CCDS5735.1
    Conserved Domains (2) summary
    cl21453
    Location:68256
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  3. NM_001350739.1NP_001337668.1  SRSF protein kinase 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070
    Conserved Domains (3) summary
    cd14217
    Location:68256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504686
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  4. NM_001350740.1NP_001337669.1  SRSF protein kinase 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (d).
    Source sequence(s)
    AC005070, AC073138
    Conserved Domains (3) summary
    cd14217
    Location:116304
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:552734
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:389431
    Na_Ca_ex; Sodium/calcium exchanger protein
  5. NM_001350741.1NP_001337670.1  SRSF protein kinase 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC005070, AC073138
    Conserved Domains (2) summary
    cl21453
    Location:79267
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:352394
    Na_Ca_ex; Sodium/calcium exchanger protein
  6. NM_001350742.1NP_001337671.1  SRSF protein kinase 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070, AC073138
    Conserved Domains (3) summary
    cd14217
    Location:105293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:541723
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378420
    Na_Ca_ex; Sodium/calcium exchanger protein
  7. NM_001350743.1NP_001337672.1  SRSF protein kinase 2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform g.
    Source sequence(s)
    AC004884, AC005070, AC073138
    Conserved Domains (3) summary
    cd14217
    Location:68256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  8. NM_001350744.1NP_001337673.1  SRSF protein kinase 2 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform g.
    Source sequence(s)
    AC004884, AC005070
    Conserved Domains (3) summary
    cd14217
    Location:68256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  9. NM_001350745.1NP_001337674.1  SRSF protein kinase 2 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070
    Conserved Domains (1) summary
    cl21453
    Location:70640
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001350746.1NP_001337675.1  SRSF protein kinase 2 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC004884, AC005070, AC073138
    Conserved Domains (3) summary
    cd14217
    Location:105293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:545610
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378420
    Na_Ca_ex; Sodium/calcium exchanger protein
  11. NM_182691.2NP_872633.1  SRSF protein kinase 2 isoform b precursor

    See identical proteins and their annotated locations for NP_872633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    BC035214, BU632662, CR746049, DA592321
    Consensus CDS
    CCDS5735.1
    UniProtKB/Swiss-Prot
    P78362
    UniProtKB/TrEMBL
    A0A024R704
    Related
    ENSP00000349863.3, OTTHUMP00000212092, ENST00000357311.7, OTTHUMT00000348716
    Conserved Domains (2) summary
    cl21453
    Location:68256
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  12. NM_182692.2NP_872634.1  SRSF protein kinase 2 isoform a

    See identical proteins and their annotated locations for NP_872634.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    BC035214, BU632662, CR746049, HY031357
    Consensus CDS
    CCDS34724.1
    UniProtKB/Swiss-Prot
    P78362
    Related
    ENSP00000377262.3, OTTHUMP00000212097, ENST00000393651.7, OTTHUMT00000348723
    Conserved Domains (2) summary
    smart00220
    Location:92236
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:79267
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    105110708..105399363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446895.1XP_024302663.1  SRSF protein kinase 2 isoform X4

    Conserved Domains (3) summary
    cd14217
    Location:116304
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:552734
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:389431
    Na_Ca_ex; Sodium/calcium exchanger protein
  2. XM_017012561.2XP_016868050.2  SRSF protein kinase 2 isoform X2

    Conserved Domains (3) summary
    cd14217
    Location:105293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:541723
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378420
    Na_Ca_ex; Sodium/calcium exchanger protein
  3. XM_024446893.1XP_024302661.1  SRSF protein kinase 2 isoform X1

    Conserved Domains (3) summary
    cd14217
    Location:105293
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:541754
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:378420
    Na_Ca_ex; Sodium/calcium exchanger protein
  4. XM_011516538.3XP_011514840.1  SRSF protein kinase 2 isoform X6

    See identical proteins and their annotated locations for XP_011514840.1

    Conserved Domains (3) summary
    cd14217
    Location:68256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  5. XM_006716098.3XP_006716161.1  SRSF protein kinase 2 isoform X6

    See identical proteins and their annotated locations for XP_006716161.1

    Conserved Domains (3) summary
    cd14217
    Location:68256
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:504717
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:341383
    Na_Ca_ex; Sodium/calcium exchanger protein
  6. XM_011516536.3XP_011514838.1  SRSF protein kinase 2 isoform X5

    Conserved Domains (2) summary
    cd14217
    Location:79267
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:515728
    PKc_like; Protein Kinases, catalytic domain
  7. XM_024446894.1XP_024302662.1  SRSF protein kinase 2 isoform X3

    Conserved Domains (3) summary
    cd14217
    Location:116304
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:552765
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:389431
    Na_Ca_ex; Sodium/calcium exchanger protein

RNA

  1. XR_001744860.2 RNA Sequence

  2. XR_001744862.2 RNA Sequence

  3. XR_001744859.2 RNA Sequence

  4. XR_001744861.2 RNA Sequence

  5. XR_001744863.2 RNA Sequence

Support Center