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Resf1 retroelement silencing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 67246, updated on 26-Sep-2022

Summary

Official Symbol
Resf1provided by MGI
Official Full Name
retroelement silencing factor 1provided by MGI
Primary source
MGI:MGI:1914496
See related
Ensembl:ENSMUSG00000032712 AllianceGenome:MGI:1914496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GET; 2810474O19Rik; 6720435I21Rik
Summary
Enables histone methyltransferase binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin assembly. Acts upstream of or within response to bacterium. Located in nucleus. Part of gamma-tubulin complex. Is expressed in limb; reproductive system; somite; and urinary system. Orthologous to human RESF1 (retroelement silencing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.3), ovary adult (RPKM 3.6) and 28 other tissues See more
Orthologs
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Genomic context

See Resf1 in Genome Data Viewer
Location:
6; 6 G3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (149210907..149237161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (149309409..149335663)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein beta subunit lysine methyltransferase Neighboring gene antagonist of mitotic exit network 1 Neighboring gene predicted gene, 38930 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1551

General protein information

Preferred Names
retroelement silencing factor 1
Names
likely orthologue of H. sapiens chromosome 12 open reading frame 35 (C12orf35)
uncharacterized protein C12orf35 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289661.1NP_001276590.1  retroelement silencing factor 1

    See identical proteins and their annotated locations for NP_001276590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC163647, AK020121, BC139436, DV644998
    Consensus CDS
    CCDS20717.1
    UniProtKB/Swiss-Prot
    Q5DTW7, Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Related
    ENSMUSP00000098328.5, ENSMUST00000100765.11
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)
  2. NM_001289662.1NP_001276591.1  retroelement silencing factor 1

    See identical proteins and their annotated locations for NP_001276591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC163647, AK020121, BC139435, DV644998
    Consensus CDS
    CCDS20717.1
    UniProtKB/Swiss-Prot
    Q5DTW7, Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Related
    ENSMUSP00000140026.2, ENSMUST00000189932.7
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)
  3. NM_026054.3NP_080330.1  retroelement silencing factor 1

    See identical proteins and their annotated locations for NP_080330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC163647, AK017376, AK020121, BC139436, DV644998
    Consensus CDS
    CCDS20717.1
    UniProtKB/Swiss-Prot
    Q5DTW7, Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Related
    ENSMUSP00000041180.7, ENSMUST00000046689.13
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    149210907..149237161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507083.4XP_006507146.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006507146.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)
  2. XM_006507081.5XP_006507144.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006507144.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)
  3. XM_006507086.5XP_006507149.1  retroelement silencing factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006507149.1

    Conserved Domains (1) summary
    pfam15395
    Location:4521470
    DUF4617; Domain of unknown function (DUF4617)
  4. XM_011241622.3XP_011239924.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011239924.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)
  5. XM_036152270.1XP_036008163.1  retroelement silencing factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)
  6. XM_006507084.4XP_006507147.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006507147.1

    UniProtKB/Swiss-Prot
    Q5DTW7, Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)
  7. XM_030255554.2XP_030111414.1  retroelement silencing factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9CU82
    UniProtKB/TrEMBL
    B2KFD2
    Related
    ENSMUSP00000139660.2, ENSMUST00000189837.2
    Conserved Domains (1) summary
    pfam15395
    Location:4521511
    DUF4617; Domain of unknown function (DUF4617)