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RESF1 retroelement silencing factor 1 [ Homo sapiens (human) ]

Gene ID: 55196, updated on 7-Jun-2020

Summary

Official Symbol
RESF1provided by HGNC
Official Full Name
retroelement silencing factor 1provided by HGNC
Primary source
HGNC:HGNC:25559
See related
Ensembl:ENSG00000174718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GET; UTA2-1; C12orf35; KIAA1551
Expression
Broad expression in lymph node (RPKM 38.5), ovary (RPKM 35.0) and 24 other tissues See more
Orthologs

Genomic context

See RESF1 in Genome Data Viewer
Location:
12p11.21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (31959415..31993107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (32112353..32146041)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 98 member B pseudogene Neighboring gene uncharacterized LOC105369725 Neighboring gene uncharacterized LOC102724618 Neighboring gene uncharacterized LOC107984473

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10652, FLJ20696

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of methylation-dependent chromatin silencing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with gamma-tubulin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
retroelement silencing factor 1
Names
gonad expressed transcript
uncharacterized protein C12orf35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018169.4NP_060639.4  retroelement silencing factor 1

    Status: VALIDATED

    Source sequence(s)
    AC016957, AC023050
    Consensus CDS
    CCDS8725.2
    Related
    ENSP00000310338.4, ENST00000312561.9
    Conserved Domains (1) summary
    pfam15395
    Location:6691737
    DUF4617; Domain of unknown function (DUF4617)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    31959415..31993107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719099.3XP_006719162.1  retroelement silencing factor 1 isoform X2

    Conserved Domains (1) summary
    pfam15395
    Location:6691668
    DUF4617; Domain of unknown function (DUF4617)
  2. XM_017019550.2XP_016875039.1  retroelement silencing factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9HCM1
    Conserved Domains (1) summary
    pfam15395
    Location:6691737
    DUF4617; Domain of unknown function (DUF4617)
  3. XM_005253405.3XP_005253462.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005253462.1

    UniProtKB/Swiss-Prot
    Q9HCM1
    Conserved Domains (1) summary
    pfam15395
    Location:6691737
    DUF4617; Domain of unknown function (DUF4617)
  4. XM_011520722.1XP_011519024.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011519024.1

    UniProtKB/Swiss-Prot
    Q9HCM1
    Conserved Domains (1) summary
    pfam15395
    Location:6691737
    DUF4617; Domain of unknown function (DUF4617)
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