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Rplp2 ribosomal protein, large P2 [ Mus musculus (house mouse) ]

Gene ID: 67186, updated on 8-Dec-2022

Summary

Official Symbol
Rplp2provided by MGI
Official Full Name
ribosomal protein, large P2provided by MGI
Primary source
MGI:MGI:1914436
See related
Ensembl:ENSMUSG00000025508 AllianceGenome:MGI:1914436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700049I22Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translational elongation. Located in synapse. Is expressed in several structures, including central nervous system and retina. Orthologous to human RPLP2 (ribosomal protein lateral stalk subunit P2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 465.0), bladder adult (RPKM 400.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rplp2 in Genome Data Viewer
Location:
7; 7 F5
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141027564..141031272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141447651..141451359)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Neighboring gene p53 induced death domain protein 1 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene predicted gene 10575

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cytoplasmic translational elongation IEA
Inferred from Electronic Annotation
more info
 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S acidic ribosomal protein P2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360657.1NP_001347586.1  60S acidic ribosomal protein P2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS40187.1
    UniProtKB/Swiss-Prot
    Q9CZJ8
    UniProtKB/TrEMBL
    A0A6P5PSV0
    Related
    ENSMUSP00000101625.2, ENSMUST00000106003.2
    Conserved Domains (1) summary
    cd05833
    Location:166
    Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...
  2. NM_001360658.1NP_001347587.1  60S acidic ribosomal protein P2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AC158224
    UniProtKB/TrEMBL
    A0A6P5PWG5
    Conserved Domains (1) summary
    cd05833
    Location:166
    Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...
  3. NM_026020.7NP_080296.3  60S acidic ribosomal protein P2 isoform a

    See identical proteins and their annotated locations for NP_080296.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC158224
    Consensus CDS
    CCDS40187.1
    UniProtKB/Swiss-Prot
    P99027, Q9CZJ8
    UniProtKB/TrEMBL
    A0A6P5PSV0
    Related
    ENSMUSP00000081474.5, ENSMUST00000084434.11
    Conserved Domains (1) summary
    cd05833
    Location:166
    Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141027564..141031272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)