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RPLP2 ribosomal protein lateral stalk subunit P2 [ Homo sapiens (human) ]

Gene ID: 6181, updated on 3-May-2020

Summary

Official Symbol
RPLP2provided by HGNC
Official Full Name
ribosomal protein lateral stalk subunit P2provided by HGNC
Primary source
HGNC:HGNC:10377
See related
Ensembl:ENSG00000177600 MIM:180530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2; LP2; RPP2; D11S2243E
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 866.8), ovary (RPKM 581.0) and 25 other tissues See more
Orthologs

Genomic context

See RPLP2 in Genome Data Viewer
Location:
11p15.5
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (809967..812876)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (808841..827592)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 22 Neighboring gene proapoptotic nucleolar protein 1 Neighboring gene p53-induced death domain protein 1 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene CD151 molecule (Raph blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational elongation IEA
Inferred from Electronic Annotation
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60S acidic ribosomal protein P2
Names
acidic ribosomal phosphoprotein P2
large ribosomal subunit protein P2
renal carcinoma antigen NY-REN-44
ribosomal protein, large, P2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004.4NP_000995.1  60S acidic ribosomal protein P2

    See identical proteins and their annotated locations for NP_000995.1

    Status: REVIEWED

    Source sequence(s)
    BC005354, BC007573
    Consensus CDS
    CCDS7717.1
    UniProtKB/Swiss-Prot
    P05387
    UniProtKB/TrEMBL
    A0A024RCA7
    Related
    ENSP00000322419.4, ENST00000321153.9
    Conserved Domains (1) summary
    cd05833
    Location:166
    Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    809967..812876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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