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Pmf1 polyamine-modulated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 67037, updated on 11-Apr-2024

Summary

Official Symbol
Pmf1provided by MGI
Official Full Name
polyamine-modulated factor 1provided by MGI
Primary source
MGI:MGI:1914287
See related
Ensembl:ENSMUSG00000028066 AllianceGenome:MGI:1914287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600009M07Rik
Summary
Predicted to enable leucine zipper domain binding activity and transcription coactivator activity. Predicted to be involved in chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of nuclear MIS12/MIND complex. Is expressed in several structures, including central nervous system; extraembryonic component; placenta; retina; and thymus. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to several human genes including PMF1-BGLAP (PMF1-BGLAP readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 35.3), ovary adult (RPKM 29.6) and 27 other tissues See more
Orthologs
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Genomic context

See Pmf1 in Genome Data Viewer
Location:
3 F1; 3 38.82 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88301445..88317752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88394138..88410445, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 6-like Neighboring gene bone gamma carboxyglutamate protein Neighboring gene solute carrier family 25, member 44 Neighboring gene STARR-positive B cell enhancer ABC_E2076 Neighboring gene 60S ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MIS12/MIND type complex ISO
Inferred from Sequence Orthology
more info
 
part_of MIS12/MIND type complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in spindle pole NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
polyamine-modulated factor 1
Names
PMF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310605.2NP_001297534.1  polyamine-modulated factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001297534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102388
    Consensus CDS
    CCDS79942.1
    UniProtKB/Swiss-Prot
    Q9CPV5
    Related
    ENSMUSP00000141696.2, ENSMUST00000193338.6
    Conserved Domains (1) summary
    pfam03980
    Location:5697
    Nnf1; Nnf1
  2. NM_025928.5NP_080204.1  polyamine-modulated factor 1 isoform 1

    See identical proteins and their annotated locations for NP_080204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102388
    Consensus CDS
    CCDS38481.1
    UniProtKB/Swiss-Prot
    Q3UCB8, Q8K237, Q924B3, Q9CPV5, Q9D6E2
    UniProtKB/TrEMBL
    Q8BVG3
    Related
    ENSMUSP00000062420.8, ENSMUST00000056370.13
    Conserved Domains (1) summary
    pfam03980
    Location:68166
    Nnf1; Nnf1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88301445..88317752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240202.3XP_011238504.1  polyamine-modulated factor 1 isoform X1

    UniProtKB/TrEMBL
    Q8BVG3
    Conserved Domains (1) summary
    pfam03980
    Location:68165
    Nnf1
  2. XM_030252766.1XP_030108626.1  polyamine-modulated factor 1 isoform X2

    Conserved Domains (1) summary
    pfam03980
    Location:68119
    Nnf1