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Pmf1 polyamine-modulated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 67037, updated on 2-Nov-2024

Summary

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Official Symbol
Pmf1provided by MGI
Official Full Name
polyamine-modulated factor 1provided by MGI
Primary source
MGI:MGI:1914287
See related
Ensembl:ENSMUSG00000028066 AllianceGenome:MGI:1914287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600009M07Rik
Summary
Predicted to enable leucine zipper domain binding activity and transcription coactivator activity. Predicted to be involved in chromosome segregation. Predicted to be located in Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of MIS12/MIND type complex. Is expressed in several structures, including central nervous system; extraembryonic component; placenta; retina; and thymus. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to human PMF1-BGLAP (PMF1-BGLAP readthrough) and PMF1 (polyamine modulated factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 35.3), ovary adult (RPKM 29.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pmf1 in Genome Data Viewer
Location:
3 F1; 3 38.82 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88301445..88317752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88394138..88410445, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 6-like Neighboring gene bone gamma carboxyglutamate protein Neighboring gene solute carrier family 25, member 44 Neighboring gene STARR-positive B cell enhancer ABC_E2076 Neighboring gene 60S ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Wang Y, et al. Biochem J, 2001 Oct 15. PMID 11583586, Free PMC Article
  2. Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene. Stephenson AH, et al. Life Sci, 2006 Aug 22. PMID 16647090
  3. Transcriptomic analysis of polyamine-related genes and polyamine levels in placenta, yolk sac and fetus during the second half of mouse pregnancy. Lopez-Garcia C, et al. Placenta, 2009 Mar. PMID 19131104
  4. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
  5. The KMN protein network--chief conductors of the kinetochore orchestra. Varma D, et al. J Cell Sci, 2012 Dec 15. PMID 23418356, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. formation of the Nrf-2/PMF-1 complex is involved in transcriptional regulation of 4E-BP1
    Title: Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables leucine zipper domain binding IEA
Inferred from Electronic Annotation
more info
  
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of MIS12/MIND type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MIS12/MIND type complex ISO
Inferred from Sequence Orthology
more info
  
part_of MIS12/MIND type complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of MIS12/MIND type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in spindle pole NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
polyamine-modulated factor 1
Names
PMF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310605.2 → NP_001297534.1  polyamine-modulated factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001297534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102388
    Consensus CDS
    CCDS79942.1
    UniProtKB/Swiss-Prot
    Q9CPV5
    Related
    ENSMUSP00000141696.2, ENSMUST00000193338.6
    Conserved Domains (1) summary
    pfam03980
    Location:56 → 97
    Nnf1; Nnf1

  2. NM_025928.5 → NP_080204.1  polyamine-modulated factor 1 isoform 1

    See identical proteins and their annotated locations for NP_080204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102388
    Consensus CDS
    CCDS38481.1
    UniProtKB/Swiss-Prot
    Q3UCB8, Q8K237, Q924B3, Q9CPV5, Q9D6E2
    UniProtKB/TrEMBL
    Q8BVG3
    Related
    ENSMUSP00000062420.8, ENSMUST00000056370.13
    Conserved Domains (1) summary
    pfam03980
    Location:68 → 166
    Nnf1; Nnf1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88301445..88317752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240202.3 → XP_011238504.1  polyamine-modulated factor 1 isoform X1

    UniProtKB/TrEMBL
    Q8BVG3
    Conserved Domains (1) summary
    pfam03980
    Location:68 → 165
    Nnf1

  2. XM_030252766.1 → XP_030108626.1  polyamine-modulated factor 1 isoform X2

    Conserved Domains (1) summary
    pfam03980
    Location:68 → 119
    Nnf1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPV5.1 GenPept UniProtKB/Swiss-Prot:Q9CPV5

Gene LinkOut

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