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PMF1 polyamine modulated factor 1 [ Homo sapiens (human) ]

Gene ID: 11243, updated on 5-Sep-2021

Summary

Official Symbol
PMF1provided by HGNC
Official Full Name
polyamine modulated factor 1provided by HGNC
Primary source
HGNC:HGNC:9112
See related
Ensembl:ENSG00000160783 MIM:609176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 21.9), thyroid (RPKM 21.3) and 25 other tissues See more
Orthologs
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Genomic context

See PMF1 in Genome Data Viewer
Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156213007..156240042)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156182779..156209868)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene semaphorin 4A Neighboring gene solute carrier family 25 member 44 Neighboring gene PMF1-BGLAP readthrough Neighboring gene BGLAP promoter region Neighboring gene bone gamma-carboxyglutamate protein Neighboring gene progestin and adipoQ receptor family member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough PMF1-BGLAP

Readthrough gene: PMF1-BGLAP, Included gene: BGLAP

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables leucine zipper domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
part_of MIS12/MIND type complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear MIS12/MIND complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
polyamine-modulated factor 1
Names
Est1p-like protein B (EST1B)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199653.2NP_001186582.1  polyamine-modulated factor 1 isoform 3

    See identical proteins and their annotated locations for NP_001186582.1

    Status: VALIDATED

    Source sequence(s)
    AL135927
    Consensus CDS
    CCDS55649.1
    UniProtKB/Swiss-Prot
    Q6P1K2
    Related
    ENSP00000357262.3, ENST00000368279.7
    Conserved Domains (1) summary
    pfam03980
    Location:71127
    Nnf1; Nnf1
  2. NM_001199654.2NP_001186583.1  polyamine-modulated factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL135927
    Consensus CDS
    CCDS55648.1
    UniProtKB/Swiss-Prot
    Q6P1K2
    Related
    ENSP00000357256.4, ENST00000368273.8
    Conserved Domains (1) summary
    pfam03980
    Location:91171
    Nnf1; Nnf1
  3. NM_001393909.1NP_001380838.1  polyamine-modulated factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL135927
  4. NM_001393910.1NP_001380839.1  polyamine-modulated factor 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL135927
  5. NM_001393911.1NP_001380840.1  polyamine-modulated factor 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL135927
  6. NM_001393912.1NP_001380841.1  polyamine-modulated factor 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL135927
    Conserved Domains (1) summary
    cl28929
    Location:67114
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
  7. NM_001393913.1NP_001380842.1  polyamine-modulated factor 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL135927
  8. NM_001393914.1NP_001380843.1  polyamine-modulated factor 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL135927
  9. NM_001393915.1NP_001380844.1  polyamine-modulated factor 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL135927
  10. NM_007221.4NP_009152.2  polyamine-modulated factor 1 isoform 2

    See identical proteins and their annotated locations for NP_009152.2

    Status: VALIDATED

    Source sequence(s)
    AL135927
    Consensus CDS
    CCDS30886.1
    UniProtKB/Swiss-Prot
    Q6P1K2
    Related
    ENSP00000357260.3, ENST00000368277.3
    Conserved Domains (1) summary
    pfam03980
    Location:71169
    Nnf1; Nnf1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156213007..156240042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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