U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pacc1 proton activated chloride channel 1 [ Mus musculus (house mouse) ]

Gene ID: 66950, updated on 11-Apr-2024

Summary

Official Symbol
Pacc1provided by MGI
Official Full Name
proton activated chloride channel 1provided by MGI
Primary source
MGI:MGI:1914200
See related
Ensembl:ENSMUSG00000026627 AllianceGenome:MGI:1914200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAC; Tmem206; 2310028N02Rik
Summary
Enables pH-gated chloride channel activity. Involved in chloride transport. Acts upstream of or within anion transmembrane transport and inorganic anion transport. Predicted to be integral component of plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human PACC1 (proton activated chloride channel 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 44.5), mammary gland adult (RPKM 41.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
1 H6; 1 96.28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191058099..191083481)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191325902..191351284)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D730003I15 gene Neighboring gene STARR-positive B cell enhancer ABC_E4407 Neighboring gene STARR-positive B cell enhancer ABC_E7786 Neighboring gene STARR-positive B cell enhancer mm9_chr1:193099421-193099721 Neighboring gene STARR-positive B cell enhancer ABC_E3354 Neighboring gene STARR-positive B cell enhancer ABC_E11113 Neighboring gene STARR-positive B cell enhancer ABC_E7787 Neighboring gene neuron derived neurotrophic factor Neighboring gene protein phosphatase 2, regulatory subunit B', alpha Neighboring gene STARR-positive B cell enhancer ABC_E10076 Neighboring gene STARR-positive B cell enhancer ABC_E7788 Neighboring gene RAB11B, member RAS oncogene family, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E177 Neighboring gene STARR-positive B cell enhancer ABC_E998 Neighboring gene poly(A) binding protein, nuclear 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 
enables pH-gated chloride channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pH-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proton-activated chloride channel
Names
transmembrane protein 206

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025864.4NP_080140.1  proton-activated chloride channel

    See identical proteins and their annotated locations for NP_080140.1

    Status: VALIDATED

    Source sequence(s)
    AC115896
    Consensus CDS
    CCDS15619.1
    UniProtKB/Swiss-Prot
    Q9D771
    UniProtKB/TrEMBL
    Q9CZV9
    Related
    ENSMUSP00000027940.6, ENSMUST00000027940.6
    Conserved Domains (1) summary
    pfam15122
    Location:55349
    TMEM206; TMEM206 protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191058099..191083481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)