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Rexo1 REX1, RNA exonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 66932, updated on 26-Sep-2022

Summary

Official Symbol
Rexo1provided by MGI
Official Full Name
REX1, RNA exonuclease 1provided by MGI
Primary source
MGI:MGI:1914182
See related
Ensembl:ENSMUSG00000047417 AllianceGenome:MGI:1914182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rex1; EloA-BP1; Tceb3bp1; 1700021P10Rik; 2610511M11Rik
Summary
Predicted to enable exonuclease activity. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 30.1), testis adult (RPKM 21.7) and 28 other tissues See more
Orthologs
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Genomic context

See Rexo1 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80376760..80400624, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80540926..80564790, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene one cut domain, family member 3 Neighboring gene ATPase, class I, type 8B, member 3 Neighboring gene predicted gene, 31057 Neighboring gene Kruppel-like factor 16 Neighboring gene predicted gene, 26710

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA exonuclease 1 homolog
Names
REX1, RNA exonuclease 1 homolog
elongin A binding protein 1
transcription elongation factor B polypeptide 3 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025852.4NP_080128.2  RNA exonuclease 1 homolog

    See identical proteins and their annotated locations for NP_080128.2

    Status: VALIDATED

    Source sequence(s)
    AC152058
    Consensus CDS
    CCDS24025.1
    UniProtKB/Swiss-Prot
    Q7TT28, Q9DA29
    Related
    ENSMUSP00000049705.9, ENSMUST00000057910.16
    Conserved Domains (2) summary
    cd06145
    Location:10531201
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:794954
    EloA-BP1; ElonginA binding-protein 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80376760..80400624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513961.4XP_006514024.1  RNA exonuclease 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006514024.1

    Conserved Domains (3) summary
    cd06145
    Location:10611209
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    PHA03307
    Location:150461
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15870
    Location:794962
    EloA-BP1; ElonginA binding-protein 1
  2. XM_011243531.3XP_011241833.1  RNA exonuclease 1 homolog isoform X3

    Conserved Domains (3) summary
    cd06145
    Location:10601208
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    PHA03307
    Location:150461
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15870
    Location:794961
    EloA-BP1; ElonginA binding-protein 1
  3. XM_011243530.3XP_011241832.1  RNA exonuclease 1 homolog isoform X1

    Conserved Domains (3) summary
    cd06145
    Location:10681216
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    PHA03307
    Location:150461
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15870
    Location:794969
    EloA-BP1; ElonginA binding-protein 1

RNA

  1. XR_004936252.1 RNA Sequence

  2. XR_004936251.1 RNA Sequence

  3. XR_004936255.1 RNA Sequence

  4. XR_003948775.1 RNA Sequence

  5. XR_871724.3 RNA Sequence

  6. XR_004936253.1 RNA Sequence

  7. XR_004936254.1 RNA Sequence