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REXO1 RNA exonuclease 1 homolog [ Homo sapiens (human) ]

Gene ID: 57455, updated on 5-Aug-2022

Summary

Official Symbol
REXO1provided by HGNC
Official Full Name
RNA exonuclease 1 homologprovided by HGNC
Primary source
HGNC:HGNC:24616
See related
Ensembl:ENSG00000079313 MIM:609614; AllianceGenome:HGNC:24616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REX1; ELOABP1; EloA-BP1; TCEB3BP1
Summary
Predicted to enable exonuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 12.3), spleen (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See REXO1 in Genome Data Viewer
Location:
19p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1815248..1848483, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1786564..1819798, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1815247..1848482, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene one cut homeobox 3 Neighboring gene uncharacterized LOC101928543 Neighboring gene ATPase phospholipid transporting 8B3 Neighboring gene Sharpr-MPRA regulatory region 3984 Neighboring gene uncharacterized LOC100288123 Neighboring gene microRNA 1909 Neighboring gene Sharpr-MPRA regulatory region 8340 Neighboring gene KLF transcription factor 16 Neighboring gene Sharpr-MPRA regulatory region 11648

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA exonuclease 1 homolog
Names
REX1, RNA exonuclease 1 homolog
elongin-A-binding protein 1
transcription elongation factor B polypeptide 3-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020695.4NP_065746.3  RNA exonuclease 1 homolog

    See identical proteins and their annotated locations for NP_065746.3

    Status: VALIDATED

    Source sequence(s)
    AC012615, BC032244
    Consensus CDS
    CCDS32866.1
    UniProtKB/Swiss-Prot
    Q8N1G1, Q9ULT2
    Related
    ENSP00000170168.3, ENST00000170168.9
    Conserved Domains (2) summary
    cd06145
    Location:10611209
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:802962
    EloA-BP1; ElonginA binding-protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1815248..1848483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027028.2XP_016882517.1  RNA exonuclease 1 homolog isoform X2

  2. XM_017027029.2XP_016882518.1  RNA exonuclease 1 homolog isoform X4

  3. XM_011528144.2XP_011526446.1  RNA exonuclease 1 homolog isoform X1

    Conserved Domains (2) summary
    cd06145
    Location:10701203
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:802962
    EloA-BP1; ElonginA binding-protein 1
  4. XM_011528146.3XP_011526448.1  RNA exonuclease 1 homolog isoform X3

    Conserved Domains (2) summary
    cd06145
    Location:10351168
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:767927
    EloA-BP1; ElonginA binding-protein 1
  5. XM_047439121.1XP_047295077.1  RNA exonuclease 1 homolog isoform X6

  6. XM_047439120.1XP_047295076.1  RNA exonuclease 1 homolog isoform X5

  7. XM_047439122.1XP_047295078.1  RNA exonuclease 1 homolog isoform X7

  8. XM_047439123.1XP_047295079.1  RNA exonuclease 1 homolog isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1786564..1819798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)