U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Asf1b anti-silencing function 1B histone chaperone [ Mus musculus (house mouse) ]

Gene ID: 66929, updated on 12-May-2024

Summary

Official Symbol
Asf1bprovided by MGI
Official Full Name
anti-silencing function 1B histone chaperoneprovided by MGI
Primary source
MGI:MGI:1914179
See related
Ensembl:ENSMUSG00000005470 AllianceGenome:MGI:1914179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIA-II; 1700003K02Rik
Summary
Enables histone binding activity. Acts upstream of or within blastocyst hatching and nucleosome assembly. Located in chromatin. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and retina. Orthologous to human ASF1B (anti-silencing function 1B histone chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 67.2), liver E14 (RPKM 56.9) and 15 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Asf1b in Genome Data Viewer
Location:
8 C2; 8 40.22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84682323..84696824)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83955694..83970195)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26721 Neighboring gene keratin 8 pseudogene Neighboring gene adhesion G protein-coupled receptor L1 Neighboring gene predicted gene 10644 Neighboring gene STARR-positive B cell enhancer ABC_E563 Neighboring gene STARR-positive B cell enhancer ABC_E8943 Neighboring gene STARR-positive B cell enhancer ABC_E361 Neighboring gene protein kinase, cAMP dependent, catalytic, alpha Neighboring gene STARR-seq mESC enhancer starr_22104 Neighboring gene sterile alpha motif domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone chaperone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone chaperone activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone chaperone ASF1B
Names
ASF1 anti-silencing function 1 homolog B
CCG1-interacting factor A-II
anti-silencing function protein 1 homolog B
mCIA-II

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024184.2NP_077146.1  histone chaperone ASF1B

    See identical proteins and their annotated locations for NP_077146.1

    Status: VALIDATED

    Source sequence(s)
    AC156028
    Consensus CDS
    CCDS22462.1
    UniProtKB/Swiss-Prot
    Q8BP41, Q9CTX3, Q9DAP7
    Related
    ENSMUSP00000005607.9, ENSMUST00000005607.9
    Conserved Domains (1) summary
    pfam04729
    Location:1154
    ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84682323..84696824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)