ASF1B anti-silencing function 1B histone chaperone [Homo sapiens (human)] - Gene

Summary

Official Symbol: ASF1Bprovided by HGNC
Official Full Name: anti-silencing function 1B histone chaperoneprovided by HGNC
Primary source: HGNC:HGNC:20996
See related: Ensembl:ENSG00000105011 MIM:609190; AllianceGenome:HGNC:20996
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CIA-II
Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]
Expression: Biased expression in testis (RPKM 18.2), lymph node (RPKM 12.4) and 13 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19p13.12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (14119512..14136589, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (14246124..14263201, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (14230324..14247401, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.
Title: The interaction between ASF1B and TLK1 promotes the malignant progression of low-grade glioma.
The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer.
Title: The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer.
Antisilencing function 1B promotes the progression of pancreatic cancer by activating cMyc.
Title: Anti‑silencing function 1B promotes the progression of pancreatic cancer by activating c‑Myc.
Downregulation of ASF1B inhibits tumor progression and enhances efficacy of cisplatin in pancreatic cancer.
Title: Downregulation of ASF1B inhibits tumor progression and enhances efficacy of cisplatin in pancreatic cancer.
Involvement of elevated ASF1B in the poor prognosis and tumorigenesis in pancreatic cancer.
Title: Involvement of elevated ASF1B in the poor prognosis and tumorigenesis in pancreatic cancer.
ASF1B enhances migration and invasion of lung cancers cell via regulating the P53-mediated epithelial-mesenchymal transformation (EMT) signaling pathway.
Title: ASF1B enhances migration and invasion of lung cancers cell via regulating the P53-mediated epithelial-mesenchymal transformation (EMT) signaling pathway.
RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.
Title: RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.
Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Title: Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Protumor Effects of Histone H3-H4 Chaperone Antisilencing Feature 1B Gene on Lung Adenocarcinoma: In Silico and In Vitro Analyses.
Title: Protumor Effects of Histone H3-H4 Chaperone Antisilencing Feature 1B Gene on Lung Adenocarcinoma: In Silico and In Vitro Analyses.
MicroRNA-520d-3p suppresses melanoma cells proliferation by inhibiting the anti-silencing function 1B histone chaperone.
Title: MicroRNA-520d-3p suppresses melanoma cells proliferation by inhibiting the anti-silencing function 1B histone chaperone.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Homologs of the ASF1B gene: The ASF1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, M.oryzae, and N.crassa.
Orthologs from Annotation Pipeline: 228 organisms have orthologs with human gene ASF1B
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables histone chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in blastocyst hatching	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: histone chaperone ASF1B

Names: ASF1 anti-silencing function 1 homolog B; CCG1-interacting factor A-II; anti-silencing function protein 1 homolog B; hAsf1; hAsf1b; hCIA-II

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.