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ASF1B anti-silencing function 1B histone chaperone [ Homo sapiens (human) ]

Gene ID: 55723, updated on 21-Dec-2019

Summary

Official Symbol
ASF1Bprovided by HGNC
Official Full Name
anti-silencing function 1B histone chaperoneprovided by HGNC
Primary source
HGNC:HGNC:20996
See related
Ensembl:ENSG00000105011 MIM:609190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIA-II
Summary
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 18.2), lymph node (RPKM 12.4) and 13 other tissues See more
Orthologs

Genomic context

See ASF1B in Genome Data Viewer
Location:
19p13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14119512..14136589, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14230321..14247440, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 1 Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene uncharacterized LOC100507373 Neighboring gene adhesion G protein-coupled receptor L1 Neighboring gene RNA, 7SL, cytoplasmic 231, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10604

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone chaperone ASF1B
Names
ASF1 anti-silencing function 1 homolog B
CCG1-interacting factor A-II
anti-silencing function protein 1 homolog B
hAsf1
hAsf1b
hCIA-II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018154.3NP_060624.1  histone chaperone ASF1B

    See identical proteins and their annotated locations for NP_060624.1

    Status: REVIEWED

    Source sequence(s)
    AK001466, BC036521
    Consensus CDS
    CCDS12306.1
    UniProtKB/Swiss-Prot
    Q9NVP2
    UniProtKB/TrEMBL
    A0A024R7G4
    Related
    ENSP00000263382.3, ENST00000263382.8
    Conserved Domains (1) summary
    pfam04729
    Location:1154
    ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14119512..14136589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160022.1 Reference GRCh38.p13 PATCHES

    Range
    331671..348748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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