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Rad21l RAD21-like (S. pombe) [ Mus musculus (house mouse) ]

Gene ID: 668929, updated on 8-Feb-2024

Summary

Official Symbol
Rad21lprovided by MGI
Official Full Name
RAD21-like (S. pombe)provided by MGI
Primary source
MGI:MGI:3652039
See related
Ensembl:ENSMUSG00000074704 AllianceGenome:MGI:3652039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm14160; Rad21l1; MeiRAD21L
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Located in lateral element. Part of nuclear meiotic cohesin complex. Is expressed in brain; gonad; and metanephros. Orthologous to human RAD21L1 (RAD21 cohesin complex component like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Rad21l in Genome Data Viewer
Location:
2 G3; 2 74.83 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151486286..151512542, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151644366..151670622, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46786 Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member E pseudogene Neighboring gene transmembrane 74B, opposite strand Neighboring gene transmembrane protein 74B Neighboring gene proteasome (prosome, macropain) inhibitor subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cohesin complex IEA
Inferred from Electronic Annotation
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
double-strand-break repair protein rad21-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276400.1NP_001263329.1  double-strand-break repair protein rad21-like protein 1

    See identical proteins and their annotated locations for NP_001263329.1

    Status: VALIDATED

    Source sequence(s)
    AB602048
    Consensus CDS
    CCDS50747.2
    UniProtKB/Swiss-Prot
    A2AU37, E5RTP6, F6KST0
    UniProtKB/TrEMBL
    R4GML2
    Related
    ENSMUSP00000136918.2, ENSMUST00000180195.8
    Conserved Domains (2) summary
    pfam04824
    Location:498549
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    151486286..151512542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500044.2XP_006500107.1  double-strand-break repair protein rad21-like protein 1 isoform X2

    UniProtKB/TrEMBL
    R4GML2
    Conserved Domains (2) summary
    pfam04824
    Location:497548
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
  2. XM_006500042.2XP_006500105.1  double-strand-break repair protein rad21-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006500105.1

    UniProtKB/Swiss-Prot
    A2AU37, E5RTP6, F6KST0
    UniProtKB/TrEMBL
    R4GML2
    Conserved Domains (2) summary
    pfam04824
    Location:498549
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
  3. XM_006500043.2XP_006500106.1  double-strand-break repair protein rad21-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006500106.1

    UniProtKB/Swiss-Prot
    A2AU37, E5RTP6, F6KST0
    UniProtKB/TrEMBL
    R4GML2
    Conserved Domains (2) summary
    pfam04824
    Location:498549
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001114677.1: Suppressed sequence

    Description
    NM_001114677.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.