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RAD21L1 RAD21 cohesin complex component like 1 [ Homo sapiens (human) ]

Gene ID: 642636, updated on 26-Oct-2022

Summary

Official Symbol
RAD21L1provided by HGNC
Official Full Name
RAD21 cohesin complex component like 1provided by HGNC
Primary source
HGNC:HGNC:16271
See related
Ensembl:ENSG00000244588 MIM:619533; AllianceGenome:HGNC:16271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAD21L; dJ545L17.2
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in mitotic sister chromatid cohesion; replication-born double-strand break repair via sister chromatid exchange; and synaptonemal complex assembly. Predicted to act upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and seminiferous tubule development. Predicted to be located in lateral element. Predicted to be part of nuclear meiotic cohesin complex and nuclear mitotic cohesin complex. Predicted to be active in synaptonemal complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 3.3) See more
Orthologs
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Genomic context

See RAD21L1 in Genome Data Viewer
Location:
20p13
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1226044..1255876)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (1273334..1303183)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1206688..1236520)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 74B Neighboring gene chromosome 20 open reading frame 202 Neighboring gene syntaphilin Neighboring gene FKBP1A-SDCBP2 readthrough (NMD candidate) Neighboring gene uncharacterized LOC124904856 Neighboring gene syndecan binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
EBI GWAS Catalog
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC198626

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in replication-born double-strand break repair via sister chromatid exchange IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of meiotic cohesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
double-strand-break repair protein rad21-like protein 1
Names
RAD21-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136566.3NP_001130038.2  double-strand-break repair protein rad21-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001130038.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL031665
    Consensus CDS
    CCDS46568.1
    UniProtKB/Swiss-Prot
    Q5W0X5, Q9H4I0
    Related
    ENSP00000386414.1, ENST00000409241.5
    Conserved Domains (2) summary
    pfam04824
    Location:502553
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
  2. NM_001384355.1NP_001371284.1  double-strand-break repair protein rad21-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL031665
    Consensus CDS
    CCDS92998.1
    UniProtKB/TrEMBL
    A0A804HJ87
    Related
    ENSP00000507397.1, ENST00000683101.1
    Conserved Domains (2) summary
    pfam04824
    Location:501552
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
  3. NM_001384356.1NP_001371285.1  double-strand-break repair protein rad21-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL031665
    Conserved Domains (1) summary
    pfam04824
    Location:343394
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
  4. NM_001384357.1NP_001371286.1  double-strand-break repair protein rad21-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL031665
    Conserved Domains (1) summary
    pfam04824
    Location:289340
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
  5. NM_001384358.1NP_001371287.1  double-strand-break repair protein rad21-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL031665
    Conserved Domains (1) summary
    pfam04824
    Location:288339
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    1226044..1255876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723603.3XP_006723666.1  double-strand-break repair protein rad21-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006723666.1

    Conserved Domains (2) summary
    pfam04824
    Location:510561
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
  2. XM_047440371.1XP_047296327.1  double-strand-break repair protein rad21-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A804HJ87
  3. XM_006723602.3XP_006723665.1  double-strand-break repair protein rad21-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006723665.1

    Conserved Domains (2) summary
    pfam04824
    Location:510561
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
  4. XM_006723604.3XP_006723667.1  double-strand-break repair protein rad21-like protein 1 isoform X2

    Conserved Domains (2) summary
    pfam04824
    Location:509560
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
  5. XM_006723605.4XP_006723668.1  double-strand-break repair protein rad21-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006723668.1

    UniProtKB/Swiss-Prot
    Q5W0X5, Q9H4I0
    Conserved Domains (2) summary
    pfam04824
    Location:502553
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
  6. XM_011529317.3XP_011527619.1  double-strand-break repair protein rad21-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527619.1

    Conserved Domains (2) summary
    pfam04824
    Location:510561
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1100
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein
  7. XM_011529320.3XP_011527622.1  double-strand-break repair protein rad21-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011527622.1

    Conserved Domains (1) summary
    pfam04824
    Location:389440
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
  8. XM_011529319.2XP_011527621.1  double-strand-break repair protein rad21-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011527621.1

    Conserved Domains (1) summary
    pfam04824
    Location:389440
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

RNA

  1. XR_937124.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    1273334..1303183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)