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Syce1l synaptonemal complex central element protein 1 like [ Mus musculus (house mouse) ]

Gene ID: 668110, updated on 8-Feb-2024

Summary

Official Symbol
Syce1lprovided by MGI
Official Full Name
synaptonemal complex central element protein 1 likeprovided by MGI
Primary source
MGI:MGI:1922247
See related
Ensembl:ENSMUSG00000033409 AllianceGenome:MGI:1922247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMRP; PSESS; mmrp2; 4930481F22Rik
Summary
Predicted to be involved in synaptonemal complex assembly. Predicted to act upstream of or within meiotic cell cycle. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in synaptonemal complex. Is expressed in colon; metanephros; spleen; submandibular gland; and testis. Orthologous to human SYCE1L (synaptonemal complex central element protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 10.9), thymus adult (RPKM 8.5) and 11 other tissues See more
Orthologs
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Genomic context

See Syce1l in Genome Data Viewer
Location:
8 E1; 8 59.65 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114369845..114382165)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (113643213..113655533)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930571O06 gene Neighboring gene predicted gene, 24291 Neighboring gene STARR-seq mESC enhancer starr_22761 Neighboring gene collagen, type III, alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22762 Neighboring gene STARR-positive B cell enhancer ABC_E1771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:116159691-116159874 Neighboring gene MON1 homolog B, secretory traffciking associated Neighboring gene predicted gene, 30052 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptonemal complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptonemal complex organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptonemal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptonemal complex central element protein 1-like
Names
meiosis-related protein
predicted second spermatocyte specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048145.1NP_001041610.1  synaptonemal complex central element protein 1-like isoform 1

    See identical proteins and their annotated locations for NP_001041610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC125463, BB616021
    Consensus CDS
    CCDS40483.1
    UniProtKB/Swiss-Prot
    B2RUQ1, Q497L4, Q5D524, Q5D525, Q9D5A5
    Related
    ENSMUSP00000092796.2, ENSMUST00000095173.3
    Conserved Domains (1) summary
    pfam15233
    Location:50172
    SYCE1; Synaptonemal complex central element protein 1
  2. NM_001286494.1NP_001273423.1  synaptonemal complex central element protein 1-like isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AK015606, BC100478, BC141326
    Consensus CDS
    CCDS85617.1
    UniProtKB/Swiss-Prot
    Q5D525
    Related
    ENSMUSP00000148356.2, ENSMUST00000212269.2
    Conserved Domains (1) summary
    pfam15233
    Location:29151
    SYCE1; Synaptonemal complex central element protein 1
  3. NM_029139.1NP_083415.1  synaptonemal complex central element protein 1-like isoform 2

    See identical proteins and their annotated locations for NP_083415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, which results in a frameshift, compared to variant 1. This encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC125463, AK015606
    Consensus CDS
    CCDS40484.1
    UniProtKB/Swiss-Prot
    Q5D525
    Related
    ENSMUSP00000034219.5, ENSMUST00000034219.12
    Conserved Domains (1) summary
    pfam15233
    Location:50130
    SYCE1; Synaptonemal complex central element protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    114369845..114382165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)