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SPAG4 sperm associated antigen 4 [ Homo sapiens (human) ]

Gene ID: 6676, updated on 17-Jun-2019

Summary

Official Symbol
SPAG4provided by HGNC
Official Full Name
sperm associated antigen 4provided by HGNC
Primary source
HGNC:HGNC:11214
See related
Ensembl:ENSG00000061656 MIM:603038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUN4; CT127
Summary
The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Broad expression in testis (RPKM 8.6), pancreas (RPKM 6.3) and 20 other tissues See more
Orthologs

Genomic context

See SPAG4 in Genome Data Viewer
Location:
20q11.22
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (35615829..35621094)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34203776..34208967)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ERGIC and golgi 3 Neighboring gene ribosomal protein L36 pseudogene 4 Neighboring gene fer-1 like family member 4 (pseudogene) Neighboring gene ribosomal protein L37 pseudogene 1 Neighboring gene copine 1 Neighboring gene RN7SK pseudogene 271 Neighboring gene RNA, U6 small nuclear 759, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein membrane anchor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal anchoring at nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motile cilium IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sperm-associated antigen 4 protein
Names
SUN domain-containing protein 4
Sad1 and UNC84 domain containing 4
acrosomal protein ACR55
cancer/testis antigen 127
outer dense fiber-associated protein SPAG4
sperm tail protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317931.1NP_001304860.1  sperm-associated antigen 4 protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in a distinct 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    BC143783, HY021678
    Conserved Domains (1) summary
    pfam07738
    Location:214345
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. NM_003116.3NP_003107.1  sperm-associated antigen 4 protein isoform 1

    See identical proteins and their annotated locations for NP_003107.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF262992, AI168233, AL109827, HY021678
    Consensus CDS
    CCDS13259.1
    UniProtKB/Swiss-Prot
    Q9NPE6
    Related
    ENSP00000363391.3, ENST00000374273.7
    Conserved Domains (1) summary
    pfam07738
    Location:291422
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    35615829..35621094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529009.2XP_011527311.1  sperm-associated antigen 4 protein isoform X1

    Conserved Domains (1) summary
    pfam07738
    Location:247378
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. XM_005260520.4XP_005260577.1  sperm-associated antigen 4 protein isoform X2

    Conserved Domains (1) summary
    pfam07738
    Location:198329
    Sad1_UNC; Sad1 / UNC-like C-terminal
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