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Spag4 sperm associated antigen 4 [ Mus musculus (house mouse) ]

Gene ID: 245865, updated on 30-Apr-2024

Summary

Official Symbol
Spag4provided by MGI
Official Full Name
sperm associated antigen 4provided by MGI
Primary source
MGI:MGI:2444120
See related
Ensembl:ENSMUSG00000038180 AllianceGenome:MGI:2444120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sun4; MNCb-0953; mKIAA4118; 1700041K21Rik
Summary
Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Predicted to be involved in nuclear envelope organization. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in microtubule. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Is expressed in brainstem; genitourinary system; and submandibular gland. Orthologous to human SPAG4 (sperm associated antigen 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 206.1) and CNS E14 (RPKM 2.7) See more
Orthologs
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Genomic context

See Spag4 in Genome Data Viewer
Location:
2 H1; 2 77.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155907108..155911421)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156065188..156069501)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene AE binding protein 2 pseudogene Neighboring gene predicted gene, 39970 Neighboring gene copine I Neighboring gene RNA binding motif protein 12 Neighboring gene STARR-seq mESC enhancer starr_06153 Neighboring gene STARR-positive B cell enhancer ABC_E3414 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene reactive oxygen species modulator 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4118, MGC130280

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sperm-associated antigen 4 protein
Names
SUN domain-containing protein 4
outer dense fiber-associated protein SPAG4
sperm antigen 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139151.4NP_631890.3  sperm-associated antigen 4 protein

    See identical proteins and their annotated locations for NP_631890.3

    Status: VALIDATED

    Source sequence(s)
    AK028080, AK043812, BY231113, BY591699
    Consensus CDS
    CCDS50777.1
    UniProtKB/Swiss-Prot
    A3KGK4, Q9JJF2
    Related
    ENSMUSP00000036484.6, ENSMUST00000038860.12
    Conserved Domains (1) summary
    pfam07738
    Location:293424
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155907108..155911421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499540.4XP_006499603.1  sperm-associated antigen 4 protein isoform X1

    Conserved Domains (2) summary
    pfam07738
    Location:214345
    Sad1_UNC; Sad1 / UNC-like C-terminal
    cl21464
    Location:574
    cupin_like; Conserved domain found in cupin and related proteins