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Pgm2 phosphoglucomutase 2 [ Mus musculus (house mouse) ]

Gene ID: 66681, updated on 2-Nov-2024

Summary

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Official Symbol
Pgm2provided by MGI
Official Full Name
phosphoglucomutase 2provided by MGI
Primary source
MGI:MGI:97564
See related
Ensembl:ENSMUSG00000029171 AllianceGenome:MGI:97564
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgm1; Pgm-1; 3230402E02Rik
Summary
Enables phosphoglucomutase activity. Involved in glycogen biosynthetic process and glycogen catabolic process. Acts upstream of or within glucose metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; liver; oocyte; respiratory system; and telencephalon. Orthologous to human PGM2 (phosphoglucomutase 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: The name of this locus, Pgm2, was recently updated by Mouse Genomic Informatics to be consistent with mammalian orthologs identified as Pgm2. Note that this gene is frequently referred to as Pgm1 in the literature. [02 Oct 2019]
Expression
Ubiquitous expression in small intestine adult (RPKM 10.1), large intestine adult (RPKM 9.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Pgm2 in Genome Data Viewer
Location:
5 C3.1; 5 32.8 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (64250258..64285698)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (64092919..64128355)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13191 Neighboring gene STARR-seq mESC enhancer starr_13192 Neighboring gene STARR-seq mESC enhancer starr_13193 Neighboring gene predicted gene, 25608 Neighboring gene STARR-positive B cell enhancer mm9_chr5:64431930-64432231 Neighboring gene RIKEN cDNA 5830416I19 gene Neighboring gene STARR-positive B cell enhancer ABC_E9641 Neighboring gene STARR-positive B cell enhancer ABC_E6330 Neighboring gene STARR-seq mESC enhancer starr_13198 Neighboring gene STARR-positive B cell enhancer mm9_chr5:64540539-64540839 Neighboring gene STARR-positive B cell enhancer ABC_E2744 Neighboring gene predicted gene, 22559 Neighboring gene TBC1 domain family, member 1 Neighboring gene STARR-seq mESC enhancer starr_13200 Neighboring gene predicted gene 15824

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Physiological correlates of an enzyme polymorphism. Brown AJ. Nature, 1977 Oct 27. PMID 927504
  2. TEM-induced gene mutations at enzyme loci in the mouse. Soares ER. Environ Mutagen, 1979. PMID 162283
  3. A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality. Balakrishnan B, et al. J Inherit Metab Dis, 2019 Sep. PMID 31077402, Free PMC Article
  4. Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5. Ihle JN, et al. Science, 1979 Apr 6. PMID 219476
  5. The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells. Myers SA, et al. PLoS One, 2013. PMID 24265765, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (4) 
  • Chemically induced (other) (1)  1 citation
  • Endonuclease-mediated (3) 
  • Spontaneous (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglucomutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoglucomutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoglucomutase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphopentomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopentomutase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphopentomutase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycogen biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine ribonucleoside salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phosphoglucomutase-2
Names
glucose phosphomutase 2
phosphodeoxyribomutase
phosphoglucomutase 1
phosphopentomutase
NP_001343893.1
NP_079976.1
XP_006504121.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356964.2 → NP_001343893.1  phosphoglucomutase-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132271
    Conserved Domains (1) summary
    PTZ00150
    Location:1 → 558
    PTZ00150; phosphoglucomutase-2-like protein; Provisional

  2. NM_001429268.1 → NP_001416197.1  phosphoglucomutase-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132271

  3. NM_025700.4 → NP_079976.1  phosphoglucomutase-2 isoform 1

    See identical proteins and their annotated locations for NP_079976.1

    Status: VALIDATED

    Source sequence(s)
    AC132271
    Consensus CDS
    CCDS19300.1
    UniProtKB/Swiss-Prot
    Q7TSV4, Q8K0P7, Q9CRS8
    Related
    ENSMUSP00000084582.6, ENSMUST00000087324.7
    Conserved Domains (1) summary
    PTZ00150
    Location:19 → 620
    PTZ00150; phosphoglucomutase-2-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    64250258..64285698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504058.3 → XP_006504121.1  phosphoglucomutase-2 isoform X1

    Conserved Domains (1) summary
    PTZ00150
    Location:1 → 452
    PTZ00150; phosphoglucomutase-2-like protein; Provisional

RNA

  1. XR_004942550.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSV4.1 GenPept UniProtKB/Swiss-Prot:Q7TSV4

Gene LinkOut

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