U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PGM2 phosphoglucomutase 2 [ Homo sapiens (human) ]

Gene ID: 55276, updated on 6-Nov-2022

Summary

Official Symbol
PGM2provided by HGNC
Official Full Name
phosphoglucomutase 2provided by HGNC
Primary source
HGNC:HGNC:8906
See related
Ensembl:ENSG00000169299 MIM:172000; AllianceGenome:HGNC:8906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSTP006
Summary
Enables phosphopentomutase activity. Predicted to be involved in carbohydrate metabolic process and deoxyribose phosphate catabolic process. Predicted to act upstream of or within glucose metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 28.0), urinary bladder (RPKM 13.5) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PGM2 in Genome Data Viewer
Location:
4p14
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (37826686..37862937)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (37795746..37832018)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (37828308..37864558)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374406 Neighboring gene ribosomal protein L21 pseudogene 45 Neighboring gene Sharpr-MPRA regulatory region 10943 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene 3

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10983

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoglucomutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphopentomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphopentomutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in purine ribonucleoside salvage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phosphopentomutase; phosphoglucomutase-2
Names
PGM 2
glucose phosphomutase 2
phosphodeoxyribomutase
NP_060760.2
XP_047271851.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018290.4NP_060760.2  phosphopentomutase

    See identical proteins and their annotated locations for NP_060760.2

    Status: VALIDATED

    Source sequence(s)
    AF109360, AI955714, BC010087, BP234074
    Consensus CDS
    CCDS3443.1
    UniProtKB/Swiss-Prot
    Q96G03, Q9NV22
    Related
    ENSP00000371393.4, ENST00000381967.9
    Conserved Domains (2) summary
    cd05799
    Location:54592
    PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...
    PTZ00150
    Location:15612
    PTZ00150; phosphoglucomutase-2-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    37826686..37862937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415895.1XP_047271851.1  phosphoglucomutase-2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    37795746..37832018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)