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Acp6 acid phosphatase 6, lysophosphatidic [ Mus musculus (house mouse) ]

Gene ID: 66659, updated on 8-Dec-2022

Summary

Official Symbol
Acp6provided by MGI
Official Full Name
acid phosphatase 6, lysophosphatidicprovided by MGI
Primary source
MGI:MGI:1931010
See related
Ensembl:ENSMUSG00000028093 AllianceGenome:MGI:1931010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACPL1; mPACPL1; 5730559A09Rik
Summary
Predicted to enable lysophosphatidic acid phosphatase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human ACP6 (acid phosphatase 6, lysophosphatidic). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 20.3), large intestine adult (RPKM 18.8) and 28 other tissues See more
Orthologs
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Genomic context

See Acp6 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97066070..97083892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97158752..97176576)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24435 Neighboring gene nuclear encoded tRNA glutamic acid 12 (anticodon CTC) Neighboring gene B cell CLL/lymphoma 9 Neighboring gene predicted gene, 40101

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophosphatidic acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysophosphatidic acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lysobisphosphatidic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lysobisphosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lysophosphatidic acid phosphatase type 6
Names
PACPL1
acid phosphatase like 1
acid phosphatase-like protein 1
NP_062774.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019800.4NP_062774.2  lysophosphatidic acid phosphatase type 6 precursor

    See identical proteins and their annotated locations for NP_062774.2

    Status: VALIDATED

    Source sequence(s)
    AC140071, AK165356
    Consensus CDS
    CCDS17653.1
    UniProtKB/Swiss-Prot
    Q8BP40, Q9QXG5
    Related
    ENSMUSP00000088263.5, ENSMUST00000090759.5
    Conserved Domains (1) summary
    cd07061
    Location:42371
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    97066070..97083892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003954368.2 RNA Sequence

  2. XR_375566.5 RNA Sequence