Tex12 testis expressed 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tex12provided by MGI
Official Full Name: testis expressed 12provided by MGI
Primary source: MGI:MGI:1913904
See related: Ensembl:ENSMUSG00000032065 AllianceGenome:MGI:1913904
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730518K06Rik
Summary: Acts upstream of or within meiotic DNA repair synthesis and synaptonemal complex assembly. Located in central element. Is expressed in oocyte and spermatocyte. Orthologous to human TEX12 (testis expressed 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 2.2), liver adult (RPKM 0.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.75 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (50468448..50472568, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (50557148..50561268, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLK1, but not PLK2-4, phosphorylates central element proteins SYCP1 and TEX12.
Title: Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.
TEX12 is a component of the central element structure of the synaptonemal complex required for propagation of synapsis along the paired homologous chromosomes and maturation of early recombination events into crossovers
Title: Progression of meiotic recombination requires structural maturation of the central element of the synaptonemal complex.
TEX12 specifically co-precipitated with SYCE2.
Title: Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tex12 (e-PCR), detects polymorphism
- UniSTS:546570

G65214 (e-PCR)
- UniSTS:225883

G65788 (e-PCR)
- UniSTS:225925

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within meiotic DNA repair synthesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic DNA repair synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptonemal complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in central element	IBA Inferred from Biological aspect of Ancestor more info
located_in central element	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed
located_in synaptonemal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: testis-expressed protein 12

Names: testis expressed gene 12; testis exprtessed gene 12; testis-expressed sequence 12 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.