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Rpe ribulose-5-phosphate-3-epimerase [ Mus musculus (house mouse) ]

Gene ID: 66646, updated on 8-Feb-2024

Summary

Official Symbol
Rpeprovided by MGI
Official Full Name
ribulose-5-phosphate-3-epimeraseprovided by MGI
Primary source
MGI:MGI:1913896
See related
Ensembl:ENSMUSG00000026005 AllianceGenome:MGI:1913896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810429B02Rik; 5730518J08Rik
Summary
Predicted to enable several functions, including monosaccharide binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Predicted to be involved in cellular carbohydrate metabolic process; pentose catabolic process; and pentose-phosphate shunt, non-oxidative branch. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to several human genes including RPE (ribulose-5-phosphate-3-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 7.6), subcutaneous fat pad adult (RPKM 7.4) and 28 other tissues See more
Orthologs
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Genomic context

See Rpe in Genome Data Viewer
Location:
1 C3; 1 33.61 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66739957..66758964)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66700797..66719805)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene predicted gene, 25411 Neighboring gene STARR-seq mESC enhancer starr_01189 Neighboring gene unc-80, NALCN activator Neighboring gene predicted gene, 39655 Neighboring gene STARR-seq mESC enhancer starr_01190 Neighboring gene STARR-seq mESC enhancer starr_01191 Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene STARR-positive B cell enhancer ABC_E5767 Neighboring gene STARR-positive B cell enhancer ABC_E11073 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:66862655-66862957 Neighboring gene STARR-positive B cell enhancer ABC_E4319 Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5768 Neighboring gene predicted gene 15793 Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-ribulose-phosphate 3-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables D-ribulose-phosphate 3-epimerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables D-ribulose-phosphate 3-epimerase activity ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pentose-phosphate shunt, non-oxidative branch ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribulose-phosphate 3-epimerase
Names
ribulose-5-phosphate-epimerase
NP_001297571.1
NP_001297572.1
NP_001297573.1
NP_079959.2
XP_006496251.1
XP_006496254.1
XP_030097961.1
XP_030097980.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310642.1NP_001297571.1  ribulose-phosphate 3-epimerase isoform 1

    See identical proteins and their annotated locations for NP_001297571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK017774, CK619266, DV651671
    Consensus CDS
    CCDS78602.1
    UniProtKB/TrEMBL
    B2KGF0, Q3UDM8
    Related
    ENSMUSP00000109628.2, ENSMUST00000113995.2
    Conserved Domains (1) summary
    cd00429
    Location:6221
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  2. NM_001310643.1NP_001297572.1  ribulose-phosphate 3-epimerase isoform 3

    See identical proteins and their annotated locations for NP_001297572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK017774, CF172967, CK619266
    UniProtKB/Swiss-Prot
    Q8VEE0
    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  3. NM_001310644.1NP_001297573.1  ribulose-phosphate 3-epimerase isoform 4

    See identical proteins and their annotated locations for NP_001297573.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 5' exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK017774, AK029088, CK619266
    UniProtKB/TrEMBL
    Q3UDM8
    Conserved Domains (1) summary
    cd00429
    Location:2174
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  4. NM_025683.3NP_079959.2  ribulose-phosphate 3-epimerase isoform 2

    See identical proteins and their annotated locations for NP_079959.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end and lacks an alternate 5' exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK017774, CK619266
    Consensus CDS
    CCDS15022.1
    UniProtKB/Swiss-Prot
    Q8C130, Q8VEE0, Q9CQZ3
    UniProtKB/TrEMBL
    Q3UDM8
    Related
    ENSMUSP00000027157.4, ENSMUST00000027157.10
    Conserved Domains (1) summary
    cd00429
    Location:6214
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    66739957..66758964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242120.2XP_030097980.1  ribulose-phosphate 3-epimerase isoform X2

    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  2. XM_006496188.4XP_006496251.1  ribulose-phosphate 3-epimerase isoform X1

    See identical proteins and their annotated locations for XP_006496251.1

    UniProtKB/TrEMBL
    Q3UDM8
    Conserved Domains (1) summary
    cd00429
    Location:6217
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  3. XM_030242101.1XP_030097961.1  ribulose-phosphate 3-epimerase isoform X2

    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  4. XM_006496191.3XP_006496254.1  ribulose-phosphate 3-epimerase isoform X2

    See identical proteins and their annotated locations for XP_006496254.1

    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...