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Rpe ribulose-5-phosphate-3-epimerase [ Mus musculus (house mouse) ]

Gene ID: 66646, updated on 9-Mar-2023

Summary

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Official Symbol
Rpeprovided by MGI
Official Full Name
ribulose-5-phosphate-3-epimeraseprovided by MGI
Primary source
MGI:MGI:1913896
See related
Ensembl:ENSMUSG00000026005 AllianceGenome:MGI:1913896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810429B02Rik; 5730518J08Rik
Summary
Predicted to enable several functions, including monosaccharide binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Predicted to be involved in cellular carbohydrate metabolic process; pentose catabolic process; and pentose-phosphate shunt, non-oxidative branch. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to several human genes including RPE (ribulose-5-phosphate-3-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 7.6), subcutaneous fat pad adult (RPKM 7.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpe in Genome Data Viewer
Location:
1; 1 C3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66739957..66758964)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66700797..66719805)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene predicted gene, 25411 Neighboring gene unc-80, NALCN activator Neighboring gene predicted gene, 39655 Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene predicted gene 15793 Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Gumaa KA, et al. Biochem J, 1969 Dec. PMID 5360673, Free PMC Article
  2. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Crozet F, et al. Genomics, 1997 Mar 1. PMID 9119401
  3. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article
  4. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

See all (26) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

  • Homologs of the Rpe gene: The Rpe gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 343 organisms have orthologs with human gene Rpe
  • Orthologs

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-ribulose-phosphate 3-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables D-ribulose-phosphate 3-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-ribulose-phosphate 3-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
  
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in pentose-phosphate shunt, non-oxidative branch ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribulose-phosphate 3-epimerase
Names
ribulose-5-phosphate-epimerase
NP_001297571.1
NP_001297572.1
NP_001297573.1
NP_079959.2
XP_006496251.1
XP_006496254.1
XP_030097961.1
XP_030097980.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310642.1 → NP_001297571.1  ribulose-phosphate 3-epimerase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK017774, CK619266, DV651671
    Consensus CDS
    CCDS78602.1
    UniProtKB/Swiss-Prot
    Q8VEE0
    UniProtKB/TrEMBL
    A0A8C6GD62, B2KGF0
    Related
    ENSMUSP00000109628.2, ENSMUST00000113995.2
    Conserved Domains (1) summary
    cd00429
    Location:6 → 221
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

  2. NM_001310643.1 → NP_001297572.1  ribulose-phosphate 3-epimerase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK017774, CF172967, CK619266
    UniProtKB/Swiss-Prot
    Q8VEE0
    UniProtKB/TrEMBL
    A0A6P7QW48
    Conserved Domains (1) summary
    cd00429
    Location:1 → 146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

  3. NM_001310644.1 → NP_001297573.1  ribulose-phosphate 3-epimerase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 5' exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK017774, AK029088, CK619266
    UniProtKB/Swiss-Prot
    Q8VEE0
    UniProtKB/TrEMBL
    A0A6P5QXJ0
    Conserved Domains (1) summary
    cd00429
    Location:2 → 174
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

  4. NM_025683.3 → NP_079959.2  ribulose-phosphate 3-epimerase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end and lacks an alternate 5' exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK017774, CK619266
    Consensus CDS
    CCDS15022.1
    UniProtKB/Swiss-Prot
    Q8VEE0, Q9CQZ3
    UniProtKB/TrEMBL
    A0A6P5QXE6, A0A8C6GDS0
    Related
    ENSMUSP00000027157.4, ENSMUST00000027157.10
    Conserved Domains (1) summary
    cd00429
    Location:6 → 214
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    66739957..66758964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242120.2 → XP_030097980.1  ribulose-phosphate 3-epimerase isoform X2

    UniProtKB/TrEMBL
    A0A6P7QW48
    Conserved Domains (1) summary
    cd00429
    Location:1 → 146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

  2. XM_006496188.4 → XP_006496251.1  ribulose-phosphate 3-epimerase isoform X1

    Conserved Domains (1) summary
    cd00429
    Location:6 → 217
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

  3. XM_030242101.1 → XP_030097961.1  ribulose-phosphate 3-epimerase isoform X2

    UniProtKB/TrEMBL
    A0A6P7QW48
    Conserved Domains (1) summary
    cd00429
    Location:1 → 146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

  4. XM_006496191.3 → XP_006496254.1  ribulose-phosphate 3-epimerase isoform X2

    UniProtKB/TrEMBL
    A0A6P7QW48
    Conserved Domains (1) summary
    cd00429
    Location:1 → 146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEE0.1 GenPept UniProtKB/Swiss-Prot:Q8VEE0

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