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RPE ribulose-5-phosphate-3-epimerase [ Homo sapiens (human) ]

Gene ID: 6120, updated on 22-Aug-2020

Summary

Official Symbol
RPEprovided by HGNC
Official Full Name
ribulose-5-phosphate-3-epimeraseprovided by HGNC
Primary source
HGNC:HGNC:10293
See related
Ensembl:ENSG00000197713 MIM:180480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPE2-1
Expression
Ubiquitous expression in thyroid (RPKM 5.9), adrenal (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See RPE in Genome Data Viewer
Location:
2q34
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (210002628..210023363)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (210867289..210889784)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microtubule associated protein 2 Neighboring gene RNA, 5S ribosomal pseudogene 118 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene snail family zinc finger 1 pseudogene 1 Neighboring gene KANSL1L antisense RNA 1 Neighboring gene KAT8 regulatory NSL complex subunit 1 like Neighboring gene ribosomal protein L6 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the RPE gene: The RPE gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 250 organisms have orthologs with human gene RPE
  • Orthologs

Clone Names

  • MGC2636

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
ribulose-phosphate 3-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribulose-phosphate 3-epimerase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pentose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
pentose-phosphate shunt TAS
Traceable Author Statement
more info
 
pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
ribulose-phosphate 3-epimerase
NP_001265211.1
NP_001265212.1
NP_001265214.1
NP_001265215.1
NP_001265217.1
NP_001265218.1
NP_001305855.1
NP_001305856.1
NP_001305857.1
NP_001305858.1
NP_001305859.1
NP_001305860.1
NP_008847.1
NP_954699.1
XP_006712740.1
XP_024308803.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278282.2NP_001265211.1  ribulose-phosphate 3-epimerase isoform 2

    See identical proteins and their annotated locations for NP_001265211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains two alternate exons, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (2) is shorter and has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 4 encode the same isoform (2).
    Source sequence(s)
    AB075523, AI222711, BC005148, BC063135
    Consensus CDS
    CCDS42810.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000401838.1, ENST00000429921.5
    Conserved Domains (1) summary
    cd00429
    Location:1164
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  2. NM_001278283.2NP_001265212.1  ribulose-phosphate 3-epimerase isoform 2

    See identical proteins and their annotated locations for NP_001265212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains two alternate exons, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (2) is shorter and has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 4 encode the same isoform (2).
    Source sequence(s)
    AB075523, AI222711, AK093658, BC005148, BC063135
    Consensus CDS
    CCDS42810.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000403808.2, ENST00000436630.6
    Conserved Domains (1) summary
    cd00429
    Location:1164
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  3. NM_001278285.2NP_001265214.1  ribulose-phosphate 3-epimerase isoform 3

    See identical proteins and their annotated locations for NP_001265214.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB075523, AI222711, AK303184, BC005148
    Consensus CDS
    CCDS63107.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000346501.7, ENST00000354506.10
    Conserved Domains (1) summary
    cd00429
    Location:6185
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  4. NM_001278286.2NP_001265215.1  ribulose-phosphate 3-epimerase isoform 4

    See identical proteins and their annotated locations for NP_001265215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains multiple differences in the coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 6, 7, 13, and 14 all encode the same isoform (4).
    Source sequence(s)
    AB075523, AI222711, AK308741, BC005148, DC403549
    Consensus CDS
    CCDS63108.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000389411.1, ENST00000411934.6
    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  5. NM_001278288.2NP_001265217.1  ribulose-phosphate 3-epimerase isoform 4

    See identical proteins and their annotated locations for NP_001265217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 6, 7, 13, and 14 all encode the same isoform (4).
    Source sequence(s)
    AB075523, AI222711, BC005148, DA237285
    Consensus CDS
    CCDS63108.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000402061.1, ENST00000438204.6
    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  6. NM_001278289.2NP_001265218.1  ribulose-phosphate 3-epimerase isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB075523, AI222711, BC005148, CN372165, CR992340, DC403549
    UniProtKB/Swiss-Prot
    Q96AT9
    Conserved Domains (1) summary
    cd00429
    Location:6188
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  7. NM_001318926.2NP_001305855.1  ribulose-phosphate 3-epimerase isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is longer compared to isoform 1. This variant encodes the longest isoform (6).
    Source sequence(s)
    AB075523, AI222711, BC005148, BX403091, DC403549
    UniProtKB/Swiss-Prot
    Q96AT9
    Conserved Domains (1) summary
    cd00429
    Location:6232
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  8. NM_001318927.2NP_001305856.1  ribulose-phosphate 3-epimerase isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (7) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB075523, AI222711, BC005148, BX643719, DC403549
    Consensus CDS
    CCDS82567.1
    UniProtKB/Swiss-Prot
    Q96AT9
    UniProtKB/TrEMBL
    C9IZU8
    Related
    ENSP00000400449.1, ENST00000452025.5
    Conserved Domains (2) summary
    cd00429
    Location:6193
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
    pfam13900
    Location:186221
    GVQW; Putative domain of unknown function
  9. NM_001318928.2NP_001305857.1  ribulose-phosphate 3-epimerase isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) contains an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (8) contains an alternate internal segment and lacks another alternate internal segment compared to isoform 1.
    Source sequence(s)
    AB075523, AI222711, BC005148, DA592494, DC403549
    UniProtKB/Swiss-Prot
    Q96AT9
    Conserved Domains (1) summary
    cd00429
    Location:6197
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  10. NM_001318929.2NP_001305858.1  ribulose-phosphate 3-epimerase isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (9) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB075523, AC007038, AI222711, BC005148, BG546879, DC403549
    Consensus CDS
    CCDS82568.1
    UniProtKB/Swiss-Prot
    Q96AT9
    UniProtKB/TrEMBL
    C9J9T0
    Related
    ENSP00000411186.1, ENST00000435437.2
    Conserved Domains (1) summary
    cd00429
    Location:6188
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  11. NM_001318930.2NP_001305859.1  ribulose-phosphate 3-epimerase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) uses an alternate splice junction in the 5' end compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 6, 7, 13, and 14 all encode the same isoform (4).
    Source sequence(s)
    AB075523, AI222711, BC005148, DA251418, DC403549
    Consensus CDS
    CCDS63108.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000386194.2, ENST00000408981.6
    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  12. NM_001318931.2NP_001305860.1  ribulose-phosphate 3-epimerase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks an alternate exon and contains another alternate exon compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 6, 7, 13, and 14 all encode the same isoform (4).
    Source sequence(s)
    AB075523, AI222711, BC005148, DA336224, DC403549
    Consensus CDS
    CCDS63108.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  13. NM_006916.3NP_008847.1  ribulose-phosphate 3-epimerase isoform 2

    See identical proteins and their annotated locations for NP_008847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains an alternate exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (2) is shorter and has a shorter N-terminus, compared to isoform 1. Variants 2, 3, and 4 encode the same isoform (2).
    Source sequence(s)
    AB075523, AI222711, AK056028, BC005148
    Consensus CDS
    CCDS42810.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000394455.1, ENST00000454822.5
    Conserved Domains (1) summary
    cd00429
    Location:1164
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  14. NM_199229.3NP_954699.1  ribulose-phosphate 3-epimerase isoform 1

    See identical proteins and their annotated locations for NP_954699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB075523, AI222711, BC005148, DC403549
    Consensus CDS
    CCDS2388.1
    UniProtKB/Swiss-Prot
    Q96AT9
    Related
    ENSP00000352401.6, ENST00000359429.11
    Conserved Domains (1) summary
    cd00429
    Location:6214
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    210002628..210023363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453035.1XP_024308803.1  ribulose-phosphate 3-epimerase isoform X1

    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
  2. XM_006712677.4XP_006712740.1  ribulose-phosphate 3-epimerase isoform X1

    See identical proteins and their annotated locations for XP_006712740.1

    UniProtKB/Swiss-Prot
    Q96AT9
    Conserved Domains (1) summary
    cd00429
    Location:1146
    RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

RNA

  1. XR_001738880.2 RNA Sequence

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