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Ubr7 ubiquitin protein ligase E3 component n-recognin 7 (putative) [ Mus musculus (house mouse) ]

Gene ID: 66622, updated on 2-Nov-2024

Summary

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Official Symbol
Ubr7provided by MGI
Official Full Name
ubiquitin protein ligase E3 component n-recognin 7 (putative)provided by MGI
Primary source
MGI:MGI:1913872
See related
Ensembl:ENSMUSG00000041712 AllianceGenome:MGI:1913872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730410I19Rik
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Is expressed in central nervous system; eye; genitourinary system; and otocyst. Orthologous to human UBR7 (ubiquitin protein ligase E3 component n-recognin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 21.0), CNS E11.5 (RPKM 20.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ubr7 in Genome Data Viewer
Location:
12 E; 12 52.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102724234..102743960)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102757975..102777701)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9862 Neighboring gene STARR-positive B cell enhancer ABC_E9390 Neighboring gene predicted gene 20604 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene STARR-seq mESC enhancer starr_33118 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene STARR-seq mESC enhancer starr_33119 Neighboring gene BTB domain containing 7 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa. Zimmerman SW, et al. Cell Tissue Res, 2014 Apr. PMID 24664117
  2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  3. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data provide the first evidence of ubiquitin ligase activity in mammalian spermatozoa and indicate UBR7 involvement in spermiogenesis.
    Title: Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative E3 ubiquitin-protein ligase UBR7
Names
N-recognin-7
RING-type E3 ubiquitin transferase UBR7
NP_079942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025666.2 → NP_079942.1  putative E3 ubiquitin-protein ligase UBR7

    See identical proteins and their annotated locations for NP_079942.1

    Status: PROVISIONAL

    Source sequence(s)
    AK088208
    Consensus CDS
    CCDS26124.1
    UniProtKB/Swiss-Prot
    Q80UT9, Q8BU04
    UniProtKB/TrEMBL
    Q3U1Z8, Q52KC0
    Related
    ENSMUSP00000041247.7, ENSMUST00000046404.8
    Conserved Domains (2) summary
    cd15542
    Location:134 → 185
    PHD_UBR7; PHD finger found in putative E3 ubiquitin-protein ligase UBR7
    pfam02207
    Location:56 → 113
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    102724234..102743960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU04.1 GenPept UniProtKB/Swiss-Prot:Q8BU04

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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