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UBR7 ubiquitin protein ligase E3 component n-recognin 7 [ Homo sapiens (human) ]

Gene ID: 55148, updated on 13-Mar-2020

Summary

Official Symbol
UBR7provided by HGNC
Official Full Name
ubiquitin protein ligase E3 component n-recognin 7provided by HGNC
Primary source
HGNC:HGNC:20344
See related
Ensembl:ENSG00000012963 MIM:613816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf130
Summary
This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in brain (RPKM 15.7), testis (RPKM 15.4) and 25 other tissues See more
Orthologs

Genomic context

See UBR7 in Genome Data Viewer
Location:
14q32.12
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (93207056..93229215)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93673401..93695561)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene transmembrane protein 251 Neighboring gene modulator of apoptosis 1 Neighboring gene ribosomal protein L18a pseudogene 1 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene ribosomal protein L36a pseudogene 4 Neighboring gene BTB domain containing 7 Neighboring gene unc-79 homolog, NALCN channel complex subunit Neighboring gene cytochrome c oxidase subunit 8C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9518, FLJ10483

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative E3 ubiquitin-protein ligase UBR7
Names
N-recognin-7
RING-type E3 ubiquitin transferase UBR7
ubiquitin protein ligase E3 component n-recognin 7 (putative)
NP_786924.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051089.1 RefSeqGene

    Range
    5201..27160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175748.4NP_786924.2  putative E3 ubiquitin-protein ligase UBR7

    See identical proteins and their annotated locations for NP_786924.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    BC051819, DB047433
    Consensus CDS
    CCDS9909.1
    UniProtKB/Swiss-Prot
    Q8N806
    Related
    ENSP00000013070.6, ENST00000013070.11
    Conserved Domains (2) summary
    cd15542
    Location:134185
    PHD_UBR7; PHD finger found in putative E3 ubiquitin-protein ligase UBR7
    pfam02207
    Location:46113
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RNA

  1. NR_038150.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the 5' region, compared to variant 2. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC051819, DA158479, DB047433

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    93207056..93229215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    321618..343777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001100417.1: Suppressed sequence

    Description
    NM_001100417.1: This RefSeq was permanently suppressed because the transcript is a nonsense-mediated mRNA decay (NMD) candidate.
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