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Chtop chromatin target of PRMT1 [ Mus musculus (house mouse) ]

Gene ID: 66511, updated on 17-Aug-2024

Summary

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Official Symbol
Chtopprovided by MGI
Official Full Name
chromatin target of PRMT1provided by MGI
Primary source
MGI:MGI:1913761
See related
Ensembl:ENSMUSG00000001017 AllianceGenome:MGI:1913761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fop; Srag; 2500003M10Rik
Summary
Predicted to enable mRNA binding activity and methyl-CpG binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be part of transcription export complex. Predicted to be active in nuclear speck. Is expressed in several structures, including alimentary system; dorsal root ganglion; integumental system; olfactory epithelium; and thymus. Orthologous to human CHTOP (chromatin target of PRMT1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.1), CNS E14 (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 39.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90405846..90417400, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90498539..90509527, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E56 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT) Neighboring gene interleukin enhancer binding factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2084 Neighboring gene SNAP-associated protein Neighboring gene STARR-positive B cell enhancer ABC_E2085 Neighboring gene STARR-seq mESC enhancer starr_08290 Neighboring gene S100 calcium binding protein A1 Neighboring gene S100 calcium binding protein A13 Neighboring gene S100 calcium binding protein A14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation. Zullo AJ, et al. J Biol Chem, 2009 May 1. PMID 19254951, Free PMC Article
  2. Fetal globin expression is regulated by Friend of Prmt1. van Dijk TB, et al. Blood, 2010 Nov 18. PMID 20688955, Free PMC Article
  3. Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. van Dijk TB, et al. Mol Cell Biol, 2010 Jan. PMID 19858291, Free PMC Article
  4. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Fanis P, et al. Mol Cell Proteomics, 2012 Nov. PMID 22872859, Free PMC Article
  5. Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Chambers DM, et al. Genome Res, 1996 Aug. PMID 8858346

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHTOP Promotes Microglia-Mediated Inflammation by Regulating Cell Metabolism and Inflammatory Gene Expression.
    Title: CHTOP Promotes Microglia-Mediated Inflammation by Regulating Cell Metabolism and Inflammatory Gene Expression.
  2. The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression.
    Title: Fetal globin expression is regulated by Friend of Prmt1.
  3. Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2).
    Title: Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromatin target of PRMT1 protein
Names
Friend of PRMT1 protein
small arginine- and glycine-rich protein
small protein rich in arginine and glycine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293776.1 → NP_001280705.1  chromatin target of PRMT1 protein isoform 1

    See identical proteins and their annotated locations for NP_001280705.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC160552, AK047914, BE852996
    Consensus CDS
    CCDS79968.1
    UniProtKB/Swiss-Prot
    Q0VBG3, Q3U7V6, Q3UF43, Q3V105, Q5XJG9, Q8C5N4, Q9CY57, Q9D7T3, Q9DB03, Q9DC54, Q9JJ95
    UniProtKB/TrEMBL
    Q2VPR3
    Related
    ENSMUSP00000061800.7, ENSMUST00000049937.13
    Conserved Domains (1) summary
    pfam13865
    Location:208 → 244
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  2. NM_001293777.1 → NP_001280706.1  chromatin target of PRMT1 protein isoform 2

    See identical proteins and their annotated locations for NP_001280706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC160552, AK047914, BE852996, CX234428
    UniProtKB/TrEMBL
    Q2VPR3
    Conserved Domains (1) summary
    pfam13865
    Location:207 → 243
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  3. NM_001293778.1 → NP_001280707.1  chromatin target of PRMT1 protein isoform 4

    See identical proteins and their annotated locations for NP_001280707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC160552, AK047914, BE852996, BQ746440
    Consensus CDS
    CCDS79967.1
    UniProtKB/TrEMBL
    E9PW20, Q2VPR3
    Related
    ENSMUSP00000102969.2, ENSMUST00000107346.8
    Conserved Domains (1) summary
    pfam13865
    Location:162 → 198
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  4. NM_001293779.1 → NP_001280708.1  chromatin target of PRMT1 protein isoform 5

    See identical proteins and their annotated locations for NP_001280708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region and lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC160552, AK005377, BE852996
    Consensus CDS
    CCDS79966.1
    UniProtKB/TrEMBL
    Q2VPR3
    Related
    ENSMUSP00000075936.5, ENSMUST00000076639.11
    Conserved Domains (1) summary
    pfam13865
    Location:161 → 197
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  5. NM_001293780.1 → NP_001280709.1  chromatin target of PRMT1 protein isoform 6

    See identical proteins and their annotated locations for NP_001280709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame compared to variant 1. One of these differences results in translation initiation at a downstream start codon compared to variant 1. The encoded isoform (6) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC160552
    Consensus CDS
    CCDS79965.1
    UniProtKB/TrEMBL
    B7ZMS6
    Related
    ENSMUSP00000102966.2, ENSMUST00000107343.8
    Conserved Domains (1) summary
    pfam13865
    Location:138 → 175
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  6. NM_001293781.1 → NP_001280710.1  chromatin target of PRMT1 protein isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame compared to variant 1. One of these differences results in translation initiation at a downstream start codon compared to variant 1. The encoded isoform (7) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC160552, AK047914, AK077960, BE852996
    Consensus CDS
    CCDS79964.1
    UniProtKB/Swiss-Prot
    Q9CY57
    Related
    ENSMUSP00000102965.2, ENSMUST00000107342.2
    Conserved Domains (1) summary
    pfam13865
    Location:136 → 172
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  7. NM_001293782.1 → NP_001280711.1  chromatin target of PRMT1 protein isoform 3

    See identical proteins and their annotated locations for NP_001280711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 8 encode the same isoform.
    Source sequence(s)
    AC160552, BC051939, BE852996
    Consensus CDS
    CCDS17532.1
    UniProtKB/TrEMBL
    Q2VPR3
    Related
    ENSMUSP00000102967.2, ENSMUST00000107344.8
    Conserved Domains (1) summary
    pfam13865
    Location:183 → 219
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

  8. NM_023215.6 → NP_075704.2  chromatin target of PRMT1 protein isoform 3

    See identical proteins and their annotated locations for NP_075704.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 8 encode the same isoform.
    Source sequence(s)
    AC160552, AK004558, BE852996
    Consensus CDS
    CCDS17532.1
    UniProtKB/TrEMBL
    Q2VPR3
    Related
    ENSMUSP00000001043.8, ENSMUST00000001043.14
    Conserved Domains (1) summary
    pfam13865
    Location:183 → 219
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90405846..90417400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941377.1 RNA Sequence

  2. XR_867226.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY57.2 GenPept UniProtKB/Swiss-Prot:Q9CY57

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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