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CHTOP chromatin target of PRMT1 [ Homo sapiens (human) ]

Gene ID: 26097, updated on 5-Jan-2020

Summary

Official Symbol
CHTOPprovided by HGNC
Official Full Name
chromatin target of PRMT1provided by HGNC
Primary source
HGNC:HGNC:24511
See related
Ensembl:ENSG00000160679 MIM:614206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOP; SRAG; SRAG-3; SRAG-5; pp7704; C1orf77; FL-SRAG; C10orf77
Summary
This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in testis (RPKM 21.4), spleen (RPKM 20.4) and 25 other tissues See more
Orthologs

Genomic context

See CHTOP in Genome Data Viewer
Location:
1q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153633982..153646306)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153606458..153618782)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A14 Neighboring gene S100 calcium binding protein A13 Neighboring gene S100 calcium binding protein A1 Neighboring gene SNAP associated protein Neighboring gene interleukin enhancer binding factor 2 Neighboring gene tRNA-iMet (anticodon CAT) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40551, MGC86949, MGC131924, DKFZp547E1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chromatin target of PRMT1 protein
Names
friend of PRMT1 protein
small protein rich in arginine and glycine

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030030.1 RefSeqGene

    Range
    5085..17325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206612.1NP_001193541.1  chromatin target of PRMT1 protein isoform 2

    See identical proteins and their annotated locations for NP_001193541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site in the coding region compared to variant 1. The resulting isoform (2) is 1 aa longer than isoform 1.
    Source sequence(s)
    AI929184, BC108721, BC120961, DC387712
    Consensus CDS
    CCDS72917.1
    UniProtKB/Swiss-Prot
    Q9Y3Y2
    Related
    ENSP00000357679.4, ENST00000368690.7
    Conserved Domains (1) summary
    pfam13865
    Location:210244
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1
  2. NM_001244664.1NP_001231593.1  chromatin target of PRMT1 protein isoform 3

    See identical proteins and their annotated locations for NP_001231593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the coding region, which results in a translational frameshift compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF318362, AL162258, BC108721, BP375397, DC387712
    Consensus CDS
    CCDS72918.1
    UniProtKB/Swiss-Prot
    Q9Y3Y2
    UniProtKB/TrEMBL
    A0A087X1B7
    Related
    ENSP00000484038.1, ENST00000614256.4
  3. NM_001317077.1NP_001304006.1  chromatin target of PRMT1 protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (4, also known as SRAG-5) is shorter, lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AF261137, AI929184, BC108721, DC387712
    Consensus CDS
    CCDS81380.1
    UniProtKB/Swiss-Prot
    Q9Y3Y2
    Related
    ENSP00000385228.1, ENST00000403433.5
    Conserved Domains (1) summary
    pfam13865
    Location:162197
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1
  4. NM_015607.4NP_056422.2  chromatin target of PRMT1 protein isoform 1

    See identical proteins and their annotated locations for NP_056422.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AF261137, AI929184, BC108721
    Consensus CDS
    CCDS1048.1
    UniProtKB/Swiss-Prot
    Q9Y3Y2
    Related
    ENSP00000357683.3, ENST00000368694.8
    Conserved Domains (1) summary
    pfam13865
    Location:209243
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153633982..153646306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000993.2XP_016856482.1  chromatin target of PRMT1 protein isoform X1

    Conserved Domains (1) summary
    pfam13865
    Location:162200
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1
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