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BNIP3L BCL2 interacting protein 3 like [ Homo sapiens (human) ]

Gene ID: 665, updated on 23-Sep-2018

Summary

Official Symbol
BNIP3Lprovided by HGNC
Official Full Name
BCL2 interacting protein 3 likeprovided by HGNC
Primary source
HGNC:HGNC:1085
See related
Ensembl:ENSG00000104765 MIM:605368; Vega:OTTHUMG00000099433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIX; BNIP3a
Summary
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in fat (RPKM 69.4), ovary (RPKM 49.9) and 24 other tissues See more
Orthologs

Genomic context

See BNIP3L in Genome Data Viewer
Location:
8p21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (26383007..26413129)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26239894..26270644)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Balpha Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene GATA motif-containing MPRA enhancer 260 Neighboring gene dnaJ homolog subfamily B member 6-like Neighboring gene uncharacterized LOC105379337

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystemPhotodynamic therapy may induce a hypoxic survival response mediated by HIF-1.
  • TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystemThe tumor suppressor TP53 (p53) exerts its tumor suppressive role in part by regulating transcription of a number of genes involved in cell death, mainly apoptotic cell death. The majority of apoptot...
  • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystemApoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and prob...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lamin binding IDA
Inferred from Direct Assay
more info
PubMed 
lamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to hypoxia IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane permeabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of autophagy of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
BCL2/adenovirus E1B 19-kd protein-interacting protein 3a
BCL2/adenovirus E1B 19kDa interacting protein 3 like
NIP-3-like protein X
NIP3-like protein X
NIP3L
adenovirus E1B19k-binding protein B5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330491.1NP_001317420.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011726, AK316315, BG942896
    Consensus CDS
    CCDS83267.1
    UniProtKB/Swiss-Prot
    O60238
    Related
    ENSP00000429851.1, ENST00000518611.5
    Conserved Domains (1) summary
    pfam06553
    Location:17178
    BNIP3; BNIP3
  2. NM_004331.2NP_004322.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

    See identical proteins and their annotated locations for NP_004322.1

    Status: REVIEWED

    Source sequence(s)
    AA946755, AB004788, AF536326, AL132665, BF337139, BQ719112, CD244492, CD558918
    Consensus CDS
    CCDS6050.1
    UniProtKB/Swiss-Prot
    O60238
    UniProtKB/TrEMBL
    Q6IBV1
    Related
    ENSP00000370003.2, OTTHUMP00000125280, ENST00000380629.6, OTTHUMT00000216895
    Conserved Domains (1) summary
    pfam06553
    Location:28218
    BNIP3; BNIP3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    26383007..26413129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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