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Bnip3l BCL2/adenovirus E1B interacting protein 3-like [ Mus musculus (house mouse) ]

Gene ID: 12177, updated on 12-May-2024

Summary

Official Symbol
Bnip3lprovided by MGI
Official Full Name
BCL2/adenovirus E1B interacting protein 3-likeprovided by MGI
Primary source
MGI:MGI:1332659
See related
Ensembl:ENSMUSG00000022051 AllianceGenome:MGI:1332659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nix; Nip3L; D14Ertd719e
Summary
Enables identical protein binding activity. Involved in regulation of autophagy of mitochondrion and regulation of protein targeting to mitochondrion. Acts upstream of or within positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human BNIP3L (BCL2 interacting protein 3 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 35.8), liver E14.5 (RPKM 29.8) and 26 other tissues See more
Orthologs
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Genomic context

See Bnip3l in Genome Data Viewer
Location:
14 D1; 14 34.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67222688..67246580, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66985238..67008877, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cold shock domain containing E1, RNA binding pseudogene Neighboring gene predicted gene, 24258 Neighboring gene STARR-positive B cell enhancer mm9_chr14:67627653-67627954 Neighboring gene protein phosphatase 2, regulatory subunit B, alpha Neighboring gene STARR-seq mESC enhancer starr_37004 Neighboring gene STARR-positive B cell enhancer ABC_E7328 Neighboring gene predicted gene, 52123

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lamin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial outer membrane permeabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein targeting to mitochondrion IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial envelope IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Names
BCL2/adenovirus E1B 19 kDa-interacting protein 3-like
BCL2/adenovirus E1B 19kDa-interacting protein 3-like
NIP3-like protein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001422131.1NP_001409060.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165148
  2. NM_001422132.1NP_001409061.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165148
  3. NM_001422133.1NP_001409062.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165148
  4. NM_001422134.1NP_001409063.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165148
  5. NM_009761.4NP_033891.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

    See identical proteins and their annotated locations for NP_033891.1

    Status: VALIDATED

    Source sequence(s)
    AC165148
    Consensus CDS
    CCDS27227.1
    UniProtKB/Swiss-Prot
    Q545J6, Q9Z2F7
    UniProtKB/TrEMBL
    Q3TEW0
    Related
    ENSMUSP00000022634.9, ENSMUST00000022634.9
    Conserved Domains (1) summary
    pfam06553
    Location:22217
    BNIP3; BNIP3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    67222688..67246580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158414.1XP_036014307.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1

    Conserved Domains (1) summary
    pfam06553
    Location:101277
    BNIP3