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Dda1 DET1 and DDB1 associated 1 [ Mus musculus (house mouse) ]

Gene ID: 66498, updated on 3-Jun-2024

Summary

Official Symbol
Dda1provided by MGI
Official Full Name
DET1 and DDB1 associated 1provided by MGI
Primary source
MGI:MGI:1913748
See related
Ensembl:ENSMUSG00000074247 AllianceGenome:MGI:1913748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500034J01Rik; 1700095J19Rik
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DDA1 (DET1 and DDB1 associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 57.3), adrenal adult (RPKM 55.6) and 28 other tissues See more
Orthologs
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Genomic context

See Dda1 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71921816..71928743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71469172..71476099)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6651 Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene anoctamin 8 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene GTP binding protein 3 Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
DET1- and DDB1-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294258.1NP_001281187.1  DET1- and DDB1-associated protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA036394, AC127416, AK032966, BY316490
    Consensus CDS
    CCDS80894.1
    UniProtKB/TrEMBL
    D3YXY5
    Related
    ENSMUSP00000123665.2, ENSMUST00000147642.2
    Conserved Domains (1) summary
    pfam10172
    Location:346
    DDA1; Det1 complexing ubiquitin ligase
  2. NM_001294259.1NP_001281188.1  DET1- and DDB1-associated protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC127416, AK032966, BY297077, BY316490
    UniProtKB/Swiss-Prot
    Q9D9Z5
    Conserved Domains (1) summary
    pfam10172
    Location:238
    DDA1; Det1 complexing ubiquitin ligase
  3. NM_025600.2NP_079876.1  DET1- and DDB1-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_079876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC127416, AK032966, BB610194, BY316490
    Consensus CDS
    CCDS52584.1
    UniProtKB/Swiss-Prot
    Q3UDQ1, Q9D9Z5
    Related
    ENSMUSP00000121042.2, ENSMUST00000124745.8
    Conserved Domains (1) summary
    pfam10172
    Location:365
    DDA1; Det1 complexing ubiquitin ligase

RNA

  1. NR_122114.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC127416, AK032966, AK149117, BY316490
    Related
    ENSMUST00000130098.8
  2. NR_122115.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC127416, AK032966, AK149980, BY316490
    Related
    ENSMUST00000135052.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71921816..71928743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242317.2XP_011240619.1  DET1- and DDB1-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10172
    Location:4790
    DDA1; Det1 complexing ubiquitin ligase