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DDA1 DET1 and DDB1 associated 1 [ Homo sapiens (human) ]

Gene ID: 79016, updated on 4-Oct-2020

Summary

Official Symbol
DDA1provided by HGNC
Official Full Name
DET1 and DDB1 associated 1provided by HGNC
Primary source
HGNC:HGNC:28360
See related
Ensembl:ENSG00000130311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCIA1; C19orf58
Expression
Ubiquitous expression in placenta (RPKM 7.7), brain (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See DDA1 in Genome Data Viewer
Location:
19p13.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17309563..17323301)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17420337..17434107)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and LEM domain containing 1 Neighboring gene abhydrolase domain containing 8 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene anoctamin 8 Neighboring gene GTP binding protein 3, mitochondrial Neighboring gene plasmalemma vesicle associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with DET1 and DDB1 associated 1 (DDA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DET1- and DDB1-associated protein 1
Names
cross-immune reaction antigen PCIA1
placenta cross-immune reaction antigen 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024050.6NP_076955.1  DET1- and DDB1-associated protein 1

    See identical proteins and their annotated locations for NP_076955.1

    Status: VALIDATED

    Source sequence(s)
    AC010463, BC000615
    Consensus CDS
    CCDS12357.1
    UniProtKB/Swiss-Prot
    Q9BW61
    UniProtKB/TrEMBL
    A0A024R7J7
    Related
    ENSP00000352928.3, ENST00000359866.9
    Conserved Domains (1) summary
    pfam10172
    Location:365
    DDA1; Det1 complexing ubiquitin ligase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17309563..17323301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451701.1XP_024307469.1  DET1- and DDB1-associated protein 1 isoform X1

    Related
    ENSP00000472171.1, ENST00000596582.1
    Conserved Domains (1) summary
    pfam10172
    Location:365
    DDA1; Det1 complexing ubiquitin ligase
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