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Ppdpf pancreatic progenitor cell differentiation and proliferation factor [ Mus musculus (house mouse) ]

Gene ID: 66496, updated on 22-Jan-2023

Summary

Official Symbol
Ppdpfprovided by MGI
Official Full Name
pancreatic progenitor cell differentiation and proliferation factorprovided by MGI
Primary source
MGI:MGI:1913746
See related
Ensembl:ENSMUSG00000016344 AllianceGenome:MGI:1913746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610012G23Rik; 2610317A05Rik; 2700038C09Rik; 3110053G12Rik
Summary
Predicted to be involved in cell differentiation. Is expressed in several structures, including esophagus; forelimb bud; and male reproductive gland or organ. Used to study non-alcoholic fatty liver disease. Orthologous to human PPDPF (pancreatic progenitor cell differentiation and proliferation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 79.8), colon adult (RPKM 67.8) and 27 other tissues See more
Orthologs
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Genomic context

See Ppdpf in Genome Data Viewer
Location:
2; 2 H4
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180828615..180830297)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181186822..181188504)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene predicted gene, 24892 Neighboring gene PTK6 protein tyrosine kinase 6 Neighboring gene predicted gene, 40033 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
pancreatic progenitor cell differentiation and proliferation factor
Names
exocrine differentiation and proliferation factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356427.1NP_001343356.1  pancreatic progenitor cell differentiation and proliferation factor isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL450341, CB202960
    Consensus CDS
    CCDS17202.1
    UniProtKB/Swiss-Prot
    Q58EU5
    Related
    ENSMUSP00000104469.2, ENSMUST00000108841.2
    Conserved Domains (1) summary
    pfam15060
    Location:1110
    PPDFL; Differentiation and proliferation regulator
  2. NM_001356428.1NP_001343357.1  pancreatic progenitor cell differentiation and proliferation factor isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL450341
    Conserved Domains (1) summary
    pfam15060
    Location:184
    PPDFL; Differentiation and proliferation regulator
  3. NM_025598.3NP_079874.1  pancreatic progenitor cell differentiation and proliferation factor isoform a

    See identical proteins and their annotated locations for NP_079874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL450341, BC058516
    Consensus CDS
    CCDS17202.1
    UniProtKB/Swiss-Prot
    Q58EU5, Q9CR37
    Related
    ENSMUSP00000016488.7, ENSMUST00000016488.13
    Conserved Domains (1) summary
    pfam15060
    Location:1110
    PPDFL; Differentiation and proliferation regulator

RNA

  1. NR_151465.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL450341
    Related
    ENSMUST00000146089.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180828615..180830297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)