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Cdc26 cell division cycle 26 [ Mus musculus (house mouse) ]

Gene ID: 66440, updated on 5-Mar-2024

Summary

Official Symbol
Cdc26provided by MGI
Official Full Name
cell division cycle 26provided by MGI
Primary source
MGI:MGI:1913690
See related
Ensembl:ENSMUSG00000066149 AllianceGenome:MGI:1913690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010012C09Rik
Summary
Predicted to be involved in protein K11-linked ubiquitination and regulation of mitotic cell cycle. Predicted to act upstream of or within cell division. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Is expressed in pancreas epithelium. Orthologous to human CDC26 (cell division cycle 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.0), limb E14.5 (RPKM 16.2) and 27 other tissues See more
Orthologs
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Genomic context

Location:
4 B3; 4 33.12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62310581..62326862, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62392344..62408625, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 31, member 2 Neighboring gene FK506 binding protein 15 Neighboring gene STARR-seq mESC enhancer starr_10422 Neighboring gene STARR-positive B cell enhancer ABC_E1277 Neighboring gene STARR-seq mESC enhancer starr_10423 Neighboring gene solute carrier family 31, member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62069546-62069847 Neighboring gene pre-mRNA processing factor 4 Neighboring gene ring finger protein 183 Neighboring gene predicted gene, 30589

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC130281

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit CDC26
Names
CDC26 subunit of anaphase promoting complex
cell division cycle protein 26 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368241.1NP_001355170.1  anaphase-promoting complex subunit CDC26

    Status: VALIDATED

    Source sequence(s)
    AL732548
    Consensus CDS
    CCDS38774.1
    UniProtKB/Swiss-Prot
    Q99JP4
    Related
    ENSMUSP00000103083.2, ENSMUST00000107459.2
  2. NM_139291.4NP_647452.1  anaphase-promoting complex subunit CDC26

    See identical proteins and their annotated locations for NP_647452.1

    Status: VALIDATED

    Source sequence(s)
    AL732548
    Consensus CDS
    CCDS38774.1
    UniProtKB/Swiss-Prot
    Q99JP4
    Related
    ENSMUSP00000081573.6, ENSMUST00000084525.12
    Conserved Domains (1) summary
    pfam10471
    Location:160
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62310581..62326862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)