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CDC26 cell division cycle 26 [ Homo sapiens (human) ]

Gene ID: 246184, updated on 7-Jun-2020

Summary

Official Symbol
CDC26provided by HGNC
Official Full Name
cell division cycle 26provided by HGNC
Primary source
HGNC:HGNC:17839
See related
Ensembl:ENSG00000176386 MIM:614533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC12; ANAPC12; C9orf17
Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.9), appendix (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See CDC26 in Genome Data Viewer
Location:
9q32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (113266992..113275579, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116029288..116037869, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 31 member 2 Neighboring gene FKBP prolyl isomerase 15 Neighboring gene uncharacterized LOC107987119 Neighboring gene solute carrier family 31 member 1 Neighboring gene pre-mRNA processing factor 4 Neighboring gene ring finger protein 183

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit CDC26
Names
CDC26 subunit of anaphase promoting complex
anaphase-promoting complex subunit 12
cell division cycle 26 homolog
cell division cycle protein 26 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139286.4NP_644815.1  anaphase-promoting complex subunit CDC26

    See identical proteins and their annotated locations for NP_644815.1

    Status: REVIEWED

    Source sequence(s)
    AL449305, BC042534, BF244254, CA446805
    Consensus CDS
    CCDS6790.1
    UniProtKB/Swiss-Prot
    Q8NHZ8
    UniProtKB/TrEMBL
    A0A024R832
    Related
    ENSP00000363322.3, ENST00000374206.4
    Conserved Domains (1) summary
    pfam10471
    Location:134
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    113266992..113275579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014575.1XP_016870064.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8
    UniProtKB/TrEMBL
    A0A024R832
    Conserved Domains (1) summary
    pfam10471
    Location:134
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26
  2. XM_017014573.1XP_016870062.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8
    UniProtKB/TrEMBL
    A0A024R832
    Conserved Domains (1) summary
    pfam10471
    Location:134
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26
  3. XM_017014574.1XP_016870063.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8
    UniProtKB/TrEMBL
    A0A024R832
    Conserved Domains (1) summary
    pfam10471
    Location:134
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26
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